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首页> 外文期刊>Frontiers in neuroendocrinology >Neurobiological bases underlying the control of the onset of puberty in the rhesus monkey: a representative higher primate.
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Neurobiological bases underlying the control of the onset of puberty in the rhesus monkey: a representative higher primate.

机译：控制恒河猴青春期发作的神经生物学基础：代表性的高等灵长类动物。

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摘要

The purpose of this article is to discuss our understanding of the neurobiological mechanisms that govern the timing of the onset of puberty in the rhesus monkey, a representative higher primate, and, whenever possible, to place findings obtained from studies of this macaque in perspective with those for the human situation. Specifically, the dynamics in the postnatal ontogeny of hypothalamic GnRH gene expression and release are described, and the roles of neuropeptide Y and gamma-aminobutyric acid in imposing the restraint on pulsatile GnRH release during juvenile development are examined. Finally, the hypothesis that circulating leptin provides the signal that times the reaugmentation of pulsatile GnRH release at the termination of juvenile development, and therefore triggers the onset of primate puberty, is discussed. Copyright 2001 Academic Press.
机译：本文的目的是讨论我们对支配恒河猴（具有代表性的高等灵长类动物）恒河猴青春期发作时间的神经生物学机制的理解，并尽可能将从该猕猴研究中获得的发现与观点相结合。那些适合人类的情况。具体而言，描述了下丘脑GnRH基因表达和释放的产后发育过程中的动力学，并研究了神经肽Y和γ-氨基丁酸在青少年发育过程中对脉冲性GnRH释放施加限制的作用。最后，讨论了循环瘦素提供的信号，该信号是在幼年发育终止时对搏动性GnRH释放进行再测量的时间，因此触发了灵长类动物青春期的发作。版权所有2001学术出版社。

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