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首页> 外文期刊>Frontiers in neuroendocrinology >Melatonin and mammary pathological growth.
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Melatonin and mammary pathological growth.

机译：褪黑激素和乳腺病理生长。

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In this article we review the state of the art on the role of the pineal gland and melatonin in mammary cancer tumorigenesis in vivo as well as in vitro. The former hypothesis of a possible role of the pineal gland in mammary cancer development was based on the evidence that the pineal, via its main secretory product, melatonin, downregulates some of the pituitary and gonadal hormones which control mammary gland development and are also responsible for the growth of hormone-dependent mammary tumors. Furthermore, melatonin could act directly on tumoral cells, thereby influencing their proliferative rate. Other possible origins of melatonin's antitumoral actions could be found in its antioxidant or immunoenhancing properties. The working hypotheses of most experiments were that the activation of the pineal gland, or the administration of melatonin, should give rise to antitumoral behavior; conversely, suppression of the pineal gland or melatonin deficits should stimulate mammary tumorigenesis. From in vivo studies on animal models of tumorigenesis, the general conclusion is that experimental manipulations activating the pineal gland, or the administration of melatonin, enlarge the latency and reduce the incidence and growth rate of chemically induced mammary tumors, while pinealectomy usually has the opposite effects. The direct actions of melatonin on mammary tumors have been suggested because of its ability to inhibit, at physiological doses (1 nM), the in vitro proliferation and invasiveness of MCF-7 human breast cancer cells. The fact that most studies have been performed on two models, chemically induced mammary adenocarcinoma in rats (in vivo studies) and the cell tumor line MCF-7 (in vitro studies), makes the generalization of the results somewhat difficult. However, the characteristics of these actions, comprising different aspects of tumor biology such as initiation, proliferation, and metastasis, as well as the doses (physiological range) at which the effect is accomplished, give special value to these findings. On the strength of these data, the small number of clinical studies focusing on the possible therapeutic value of melatonin on breast cancer is surprising. Copyright 2000 Academic Press.
机译：在本文中，我们回顾了松果体和褪黑激素在体内和体外在乳癌肿瘤发生中的作用的最新技术。松果体在乳癌发展中可能发挥作用的先前假设是基于以下证据：松果体通过其主要分泌产物褪黑激素下调了一些垂体和性腺激素，这些激素控制着乳腺的发育，并且也负责激素依赖性乳腺肿瘤的生长。此外，褪黑激素可以直接作用于肿瘤细胞，从而影响其增殖率。褪黑素的抗肿瘤作用的其他可能的起源可以发现其抗氧化剂或免疫增强特性。大多数实验的可行假设是，松果体的激活或褪黑激素的使用应引起抗肿瘤行为。相反，抑制松果体或褪黑激素缺乏会刺激乳腺肿瘤的发生。从对肿瘤发生的动物模型的体内研究中，普遍的结论是激活松果体的实验操作或褪黑激素的施用会增加化学诱导的乳腺肿瘤的潜伏期并降低其发生率和增长率，而松果体切除术通常具有相反的效果效果。已经提出了褪黑激素对乳腺肿瘤的直接作用，因为其能够以生理剂量（1nM）抑制MCF-7人乳腺癌细胞的体外增殖和侵袭性。大多数研究已在两种模型上进行，即大鼠化学诱导的乳腺腺癌（体内研究）和细胞瘤系MCF-7（体外研究），这一事实使结果的推广有些困难。然而，这些作用的特征，包括肿瘤生物学的不同方面，例如起始，增殖和转移，以及达到作用的剂量（生理范围），对这些发现具有特殊价值。基于这些数据，很少有临床研究关注褪黑激素对乳腺癌的可能治疗价值。版权所有2000学术出版社。

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