...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in neuroendocrinology >Leptin regulation of neuroendocrine systems.
【24h】

Leptin regulation of neuroendocrine systems.

机译：瘦素调节神经内分泌系统。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The discovery of leptin has enhanced understanding of the interrelationship between adipose energy stores and neuronal circuits in the brain involved in energy balance and regulation of the neuroendocrine axis. Leptin levels are dependent on the status of fat stores as well as changes in energy balance as a result of fasting and overfeeding. Although leptin was initially thought to serve mainly as an anti-satiety hormone, recent studies have shown that it mediates the adaptation to fasting. Furthermore, leptin has been implicated in the regulation of the reproductive, thyroid, growth hormone, and adrenal axes, independent of its role in energy balance. Although it is widely known that leptin acts on hypothalamic neuronal targets to regulate energy balance and neuroendocrine function, the specific neuronal populations mediating leptin action on feeding behavior and autonomic and neuroendocrine function are not well understood. In this review, we have discussed how leptin engages arcuate hypothalamic neurons expressing putative orexigenic peptides, e.g., neuropeptide Y and agouti-regulated peptide, and anorexigenic peptides, e.g., pro-opiomelanocortin (precursor of alpha-melanocyte-stimulating hormone) and cocaine- and amphetamine-regulated transcript. We show that leptin's effects on energy balance and the neuroendocrine axis are mediated by projections to other hypothalamic nuclei, e.g., paraventricular, lateral, and perifornical areas, as well as other sites in the brainstem, spinal cord, and cortical and subcortical regions. Copyright 2000 Academic Press.
机译：瘦素的发现增强了人们对参与能量平衡和神经内分泌轴调节的大脑中脂肪储能与神经元回路之间相互关系的理解。瘦素水平取决于脂肪储存的状态以及禁食和过量喂养导致的能量平衡变化。尽管最初认为瘦素主要用作抗饱腹感激素，但最近的研究表明，瘦素可以介导对禁食的适应。此外，瘦素与生殖，甲状腺，生长激素和肾上腺轴的调节有关，而与其在能量平衡中的作用无关。虽然众所周知瘦蛋白作用于下丘脑神经元靶标以调节能量平衡和神经内分泌功能，但是对瘦蛋白介导进食行为以及植物神经和内分泌功能的特定神经元群体知之甚少。在这篇综述中，我们讨论了瘦素如何与表达假定的致食性肽（例如，神经肽Y和古古替调节肽）的弓形下丘脑神经元结合，以及促厌食性肽（例如促黑素皮质激素（α-黑素细胞刺激激素的前体）和可卡因）和苯丙胺调节的转录本我们表明瘦素对能量平衡和神经内分泌轴的影响是由对其他下丘脑核的投射介导的，例如，脑室旁，外侧和肾盂旁区域以及脑干，脊髓以及皮质和皮质下区域的其他部位。版权所有2000学术出版社。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号