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首页> 外文期刊>Frontiers in neuroendocrinology >Rapid, nongenomic steroid actions: A new age?
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Rapid, nongenomic steroid actions: A new age?

机译：快速，非基因组的类固醇作用：新时代？

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In the traditional theory of steroid action, steroids bind to intracellular receptors and modulate nuclear transcription after translocation of steroid-receptor complexes into the nucleus. Due to similarities of molecular structure, specific receptors for steroids, vitamin D(3) derivatives, and thyroid hormone are considered to represent a superfamily of steroid receptors. While genomic steroid effects characterized by their delayed onset of action and their sensitivity to blockers of transcription and protein synthesis have been known for several decades, rapid actions of steroids have been more widely recognized and characterized in detail only recently. Rapid effects of steroids, thyroid hormones, and the steroid hormone metabolite of vitamin D(3), 1alpha, 25-dihydroxyvitamin D(3), on cellular signaling and function may be transmitted by specific membrane receptors. Binding sites in membranes have been characterized, exposing binding features compatible with an involvement in rapid steroid signaling. Characteristics of putative membrane receptors are completely distinct from intracellular steroid receptors, a fact which is further supported by the inability of classic steroid receptor antagonists to block nongenomic steroid actions. A putative progesterone membrane receptor has been cloned and functionally expressed with regard to progesterone binding. Development of drugs that specifically affect nongenomic action alone or even both modes of action may find applications in various, areas such as in the cardiovascular and central nervous systems and treatment of preterm labor, infertility, and electrolyte abnormalities. Copyright 2000 Academic Press.
机译：在类固醇作用的传统理论中，类固醇与细胞内受体结合并在类固醇-受体复合物移位进入细胞核后调节核转录。由于分子结构的相似性，类固醇，维生素D（3）衍生物和甲状腺激素的特定受体被认为代表类固醇受体的超家族。尽管几十年来人们已经知道以基因组类固醇的作用为特征的起效延迟及其对转录和蛋白质合成阻滞剂的敏感性，但直到最近，类固醇的快速作用才被更广泛地认识和表征。类固醇，甲状腺激素和维生素D（3），1α，25-二羟基维生素D（3）的类固醇激素代谢产物对细胞信号传导和功能的快速作用可能是通过特定的膜受体传递的。膜中的结合位点已被表征，暴露出与快速类固醇信号传导有关的结合特征。推定的膜受体的特性与细胞内类固醇受体完全不同，这一事实进一步得到经典类固醇受体拮抗剂不能阻断非基因组类固醇作用的支持。假定的孕酮膜受体已被克隆，并在功能上表达了有关孕激素的结合。专门单独影响非基因组作用或什至同时影响两种作用方式的药物的开发可能会在各种领域中找到应用，例如在心血管和中枢神经系统以及早产，不育和电解质异常的治疗中。版权所有2000学术出版社。

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