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首页> 外文期刊>Frontiers in neuroendocrinology >Animal models of CRH deficiency.
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Animal models of CRH deficiency.

机译：CRH缺乏症的动物模型。

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Corticotropin-releasing hormone (CRH), the major regulator of hypothalamic-pituitary-adrenal (HPA) axis, was first isolated due to its ability to stimulate the release of adrenocorticotropic hormone from the anterior pituitary. Later, it was also found to have also a wide spectrum of actions within the central nervous system and the periphery. Studies with pharmacological administration of this peptide and/or antagonists and antibody neutralization techniques have yielded important information concerning the physiological relevance of CRH. The development of CRH knockout mice (CRH KO) has been an important tool for addressing the physiologic and pathologic roles of CRH. This review describes the phenotype of CRH-deficient mice, as well as the use of this model to study the roles of CRH on fetal development and postnatal life. The role of CRH in prenatal development and postnatal regulation of the HPA axis, in activation of the reproductive system during stress, and in modulation of the immune function will be discussed. The review concludes with a comparison of CRH KO mice with other models of CRH deficiency. Copyright 1999 Academic Press.
机译：促肾上腺皮质激素释放激素（CRH）是下丘脑-垂体-肾上腺（HPA）轴的主要调节剂，由于其具有刺激垂体前叶释放促肾上腺皮质激素的能力，因此首次被分离出来。后来，还发现它在中枢神经系统和周围区域也具有广泛的作用。对该肽和/或拮抗剂的药理学研究和抗体中和技术的研究已获得有关CRH生理相关性的重要信息。 CRH基因敲除小鼠（CRH KO）的发展已成为解决CRH的生理和病理作用的重要工具。这篇综述描述了CRH缺陷型小鼠的表型，以及使用该模型研究CRH在胎儿发育和产后生活中的作用。将讨论CRH在产前发育和HPA轴的产后调节，应激过程中生殖系统的活化以及免疫功能的调节中的作用。审查的结论是将CRH KO小鼠与其他CRH缺乏模型进行比较。版权所有1999 Academic Press。

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