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首页> 外文期刊>Frontiers in neuroendocrinology >Gonadotropin-releasing hormone genes: phylogeny, structure, and functions.
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Gonadotropin-releasing hormone genes: phylogeny, structure, and functions.

机译：促性腺激素释放激素基因：系统发育，结构和功能。

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摘要

Gonadotropin-releasing hormone (GnRH, previously called leutinizing hormone-releasing hormone, LHRH) is the final common signaling molecule used by the brain to regulate reproduction in all vertebrates. Recently, genes encoding two other GnRH forms have been discovered. Here we present a phylogenetic analysis that shows that the GnRH genes fall naturally into three distinct branches, each of which shares not only a molecular signature but also characteristic expression sites in the brain. The GnRH genes appear to have arisen through gene duplication from a single ancestral GnRH whose origin predates vertebrates. Several lines of data support this suggestion, including the fact that all three genes share an identical exonic structure. The existence of three distinct GnRH families suggests a new, natural nomenclature for the genes, and in addition, we present a logical proposal for naming the peptide sequences. The two recently discovered GnRH genes are unusual because they encode decapeptides that are identical in all the species in which they have been found. The control of gene expression also differs among the three gene families as might be expected since they have had separate evolutionary trajectories for perhaps 500 million years. Copyright 1999 Academic Press.
机译：促性腺激素释放激素（GnRH，以前称为亮化激素释放激素，LHRH）是大脑用来调节所有脊椎动物繁殖的最终常见信号分子。最近，已经发现了编码其他两种GnRH形式的基因。在这里，我们进行系统发育分析，结果表明GnRH基因自然分为三个不同的分支，每个分支不仅共享分子签名，而且还共享大脑中的特征性表达位点。 GnRH基因似乎是由单一祖先GnRH的基因复制产生的，其起源早于脊椎动物。几行数据支持这一建议，包括所有三个基因都具有相同的外显子结构的事实。三个不同的GnRH家族的存在暗示了该基因的新的自然命名法，此外，我们提出了命名肽序列的合乎逻辑的建议。最近发现的两个GnRH基因很不寻常，因为它们编码的十肽在发现它们的所有物种中都是相同的。可以预期，这三个基因家族之间的基因表达控制也有所不同，因为它们有大约5亿年的独立进化轨迹。版权所有1999 Academic Press。

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