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首页> 外文期刊>Frontiers in neuroendocrinology >Steroidogenic factor-1: its role in endocrine organ development and differentiation.
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Steroidogenic factor-1: its role in endocrine organ development and differentiation.

机译：类固醇生成因子-1：其在内分泌器官发育和分化中的作用。

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The cloning of the first steroid hormone receptor over a decade ago provided vital insight into the mechanisms by which steroid hormones activate gene transcription. When bound by hormone, these receptors function as ligand-dependent transcription factors by binding to unique response elements in the promoter of specific target genes. Over 60 receptors have now been characterized in this superfamily of steroid receptors. Many receptors known as orphan receptors have been cloned by homology and have no known ligands but appear to be mediators of endocrine function in the adult and in many cases are essential developmental regulators in endocrine organogenesis. One such receptor is steroidogenic factor-1 (SF-1). While initially cloned as a transcriptional regulator of the various steroidogenic enzyme genes in the adrenal and gonad, it has become clear through genetic ablation experiments in mice that SF-1 is an essential factor in adrenal and gonadal development and for the proper functioning of the hypothalamic-pituitary-gonadal axis. In addition, these studies have revealed that SF-1 is necessary for the formation of the ventromedial nucleus of the hypothalamus. While we have learned much since the initial cloning of SF-1, the mechanisms by which SF-1 regulates these various developmental programs remain elusive. This article focuses on the characterization of SF-1 and its emerging role in endocrine homeostasis. Specific attention is placed on the mechanisms of action of this unique member of the nuclear receptor superfamily. Copyright 1999 Academic Press.
机译：十年前，第一个类固醇激素受体的克隆为类固醇激素激活基因转录的机制提供了重要的见识。当与激素结合时，这些受体通过与特定靶基因启动子中的独特应答元件结合而起配体依赖性转录因子的作用。现在已经在该类固醇受体超家族中鉴定出60多种受体。已经通过同源性克隆了许多称为孤儿受体的受体，它们没有已知的配体，但似乎是成人内分泌功能的介质，并且在许多情况下是内分泌器官发生中必不可少的发育调节剂。一种这样的受体是类固醇生成因子-1（SF-1）。当最初被克隆为肾上腺和性腺中各种类固醇生成酶基因的转录调节因子时，通过小鼠的基因消融实验已经清楚了SF-1是肾上腺和性腺发育以及下丘脑正常功能的重要因素。 -垂体-性腺轴。另外，这些研究表明SF-1对于下丘脑腹膜内侧核的形成是必需的。自从SF-1最初克隆以来我们已经学到了很多东西，但是SF-1调节这些各种发育程序的机制仍然难以捉摸。本文重点介绍SF-1的特性及其在内分泌稳态中的新兴作用。特别注意核受体超家族这一独特成员的作用机理。版权所有1999 Academic Press。

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