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首页> 外文期刊>American journal of medical genetics, Part A >Pregnancy outcome of fetuses with trisomy 18 identified by prenatal sonography and chromosomal analysis in a perinatal center.
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Pregnancy outcome of fetuses with trisomy 18 identified by prenatal sonography and chromosomal analysis in a perinatal center.

机译：通过围产期中心的产前超声检查和染色体分析确定的18三体胎儿的妊娠结局。

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To investigate the pregnancy outcome of fetuses affected with trisomy 18, we analyzed 63 cases diagnosed at our hospital from January 1993 to December 2004. Twenty-nine were males and 34 were females. Fifty-eight were prenatally diagnosed, and in 16 (27.6%) of them intrauterine fetal death (IUFD) occurred between 28 weeks and 41 weeks gestation (34.6 +/- 3.9 weeks, Mean +/- SD). Ten (17.2%) fetuses died during labor and their age ranged from 30 weeks to 40 weeks of gestation. The total number of cases ending in fetal demise was 26 (44.8%) and the mean gestational age at the time of fetal demise was 35.0 +/- 3.6 weeks (Mean +/- SD). All liveborn infants (n = 36) were born after 31 weeks gestation. In our study the preterm birth ratio for trisomy 18 is 34.8%, which is much higher than the ratio for the general population. Females are more likely than males to be long-term survivors. These data are helpful in the counseling of parents faced with the difficult decision of whether or not to continue a pregnancy with a fetus affected with trisomy 18.
机译：为了调查受18三体综合症影响的胎儿的妊娠结局，我们分析了1993年1月至2004年12月在我院诊断出的63例病例。其中男29例，女34例。有58名被产前诊断，其中16名（27.6％）在宫内胎儿死亡（IUFD）发生在妊娠28周至41周之间（34.6 +/- 3.9周，平均值+/- SD）。十名（17.2％）的胎儿在分娩时死亡，其年龄从30周到40周不等。以胎儿死亡结束的病例总数为26（44.8％），胎儿死亡时的平均胎龄为35.0 +/- 3.6周（平均+/- SD）。所有活产婴儿（n = 36）均在妊娠31周后出生。在我们的研究中，18三体的早产率为34.8％，远高于普通人群的比例。女性比男性更有可能成为长期幸存者。这些数据有助于为面临艰难决定的父母提供咨询，该决定是否要继续使受18三体性影响的胎儿继续怀孕。

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