Synthesis, cytotoxicity, and apoptosis induction study of antitumor dinuclear platinum(II) complexes

XuG.; GouS.; GaoC.

首页> 外文期刊>Archiv der Pharmazie >Synthesis, cytotoxicity, and apoptosis induction study of antitumor dinuclear platinum(II) complexes

【24h】

Synthesis, cytotoxicity, and apoptosis induction study of antitumor dinuclear platinum(II) complexes

机译：抗肿瘤双核铂（II）配合物的合成，细胞毒性和凋亡诱导研究

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Five novel dinuclear platinum(II) complexes with a new chiral ligand, 3-(2-amino-cyclohexylamino)-propionic acid (HP), were designed, prepared and spectrally characterized. The in vitro cytotoxicities of these compounds were evaluated against the HepG-2, MCF-7, A549, and HCT-116 cell lines. The results indicated that all compounds showed cytotoxicity towards the HepG-2 cell line. Particularly, complex X5, which has SO 42- as a bridge, exhibited better cytotoxicity than carboplatin or oxaliplatin against all selected cell lines. Moreover, double dyeing flow cytometric resection indicated that the target compounds inhibited tumor cell growth by inducing apoptosis. Five novel dinuclear platinum(II) complexes with a new chiral ligand, 3-(2-amino- cyclohexylamino)-propionic acid, were designed. The in vitro cytotoxicity results of these compounds against the HepG-2, MCF-7, A549, and HCT-116 cell lines indicated that all compounds showed cytotoxicity towards the HepG-2 cell line. Particularly, complex X5, which has SO 42- as a bridge, exhibited better cytotoxicity than carboplatin or oxaliplatin against all selected cell lines.

机译：设计，制备和光谱表征了五个具有新的手性配体3-（2-氨基-环己基氨基）-丙酸（HP）的新型双核铂（II）配合物。评估了这些化合物对HepG-2，MCF-7，A549和HCT-116细胞系的体外细胞毒性。结果表明，所有化合物均显示出对HepG-2细胞系的细胞毒性。特别地，具有SO 42-作为桥的络合物X5对所有选择的细胞系表现出比卡铂或奥沙利铂更好的细胞毒性。此外，双染色流式细胞术切除表明目标化合物通过诱导凋亡来抑制肿瘤细胞的生长。设计了五种具有新手性配体3-（2-氨基-环己基氨基）-丙酸的新型双核铂（II）配合物。这些化合物对HepG-2，MCF-7，A549和HCT-116细胞系的体外细胞毒性结果表明，所有化合物均对HepG-2细胞系显示出细胞毒性。特别地，具有SO 42-作为桥的络合物X5对所有选择的细胞系表现出比卡铂或奥沙利铂更好的细胞毒性。

著录项

来源
《Archiv der Pharmazie》 |2013年第4期|共6页
作者
XuG.; GouS.; GaoC.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 ger
中图分类药学;
关键词
3-(2-Amino-cyclohexylamino)-propionic acid; Apoptosis induction; Cytotoxicity; Dinuclear platinum complex;

机译：3-（2-氨基-环己基氨基）-丙酸;凋亡诱导;细胞毒性;双核铂络合物;

相似文献

外文文献
中文文献
专利

1. Synthesis, cytotoxicity, and apoptosis induction study of antitumor dinuclear platinum(II) complexes [J] . XuG., GouS., GaoC. Archiv der Pharmazie . 2013,第4期

机译：抗肿瘤双核铂（II）配合物的合成，细胞毒性和凋亡诱导研究
2. New antitumor-active azole-bridged dinuclear platinum(II) complexes: Synthesis, characterization, crystal structures, and cytotoxic studies [J] . Komeda S., Spek AL., Chikuma M., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2000,第19期

机译：新型抗肿瘤活性的唑桥双核铂（II）配合物：合成，表征，晶体结构和细胞毒性研究
3. Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: Synthesis, characterization, cytotoxicity, cell cycle and apoptosis [J] . Qin Qi-Pin, Chen Zhen-Feng, Qin Jiao-Lan, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2015,第Null期

机译：两种平面八-羟基喹啉铂（II）配合物的抗肿瘤机制研究：合成，表征，细胞毒性，细胞周期和凋亡
4. Action of newly developed tetrazolato-bridged dinuclear platinum(II) complexe as the candidate of effective antitumor drug on the structure of large DNA [C] . Shinsuke Masuoka, Yuta Shimizu, Yuko Yoshikawa, International Symposium on Micro-NanoMechatronics and Human Science . 2016

机译：新开发的四唑桥联双核铂（II）配合物作为有效抗肿瘤药物候选物对大DNA结构的作用
5. Electrophilic late transition metal complexes of platinum(II) and iridium(III): Rational design, synthesis, and study. [D] . Albietz, Paul John, Jr. 2001

机译：铂（II）和铱（III）的亲电晚过渡金属配合物：合理的设计，合成和研究。
6. Synthesis Structural Characterization and Cytotoxic Activity of Novel Paramagnetic Platinum Hematoporphyrin IX Complexes: Potent Antitumor Agents [O] . G. Gencheva, D. Tsekova, G. Gochev, 2007

机译：新型顺磁性铂血卟啉IX配合物的合成结构表征和细胞毒活性：高效抗肿瘤药。
7. A Novel Isomerization on Interaction of Antitumor-Active Azole-Bridged Dinuclear Platinum(II) Complexes with 9-Ethylguanine. Platinum(II) Atom Migration from N2 to N3 on 1,2,3-Triazole. [O] . Komeda, S., Lutz, M.H., Spek, A.L., 2002

机译：抗肿瘤活性唑配合双核铂（II）配合物与9-乙基鸟嘌呤相互作用的新异构化。铂（II）原子在1,2,3-三唑上从N2迁移到N3。
8. Synthesis and X-ray Crystal Structures of (Au(CH2)2PPh2)2(CF3)2, (Au(CH2)2PPh2)2(C6F5)2, and (PPN)(Au(C6F5)4): Two Dinuclear Gold (II) Ylide Complexes Containing Alkyl and Aryl Ligands and a Tetrakis(pentafluorophenyl)aurate(III) [R] . Murray, H. H., Fackler, J. P., Porter, L. C., 1987

机译：（au（CH2）2pph2）2（CF3）2，（au（CH2）2pph2）2（C6F5）2和（ppN）（au（C6F5）4）的合成和X射线晶体结构：两个双核金（ II）含有烷基和芳基配体的Ylide配合物和四（五氟苯基）丙酸酯（III）

Synthesis, cytotoxicity, and apoptosis induction study of antitumor dinuclear platinum(II) complexes

摘要

著录项

相似文献

相关主题

期刊订阅