Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate.

Molinari A; Oliva A; Ojeda

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Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate.

机译：1,4-萘氢醌-1,4-二乙酸酯的6-（3-吡唑基丙基）衍生物的合成和细胞毒性评估。

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Several new 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate (NHQ-DA) have been prepared by chemical modifications of the Diels-Alder adduct of alpha-myrcene and 1,4-benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB-231 breast-adeno carcinoma, A-549 lung carcinoma, and HT-29 colon carcinoma. GI(50) values ranged in and below the micromolar concentration level.

机译：1,4-萘氢醌-1,4-二乙酸酯（NHQ-DA）的几种新的6-（3-吡唑基丙基）衍生物是通过对α-月桂烯和1,4-苯醌的Diels-Alder加合物进行化学修饰而制备的。所有这些新化合物和前体已在体外评估了其对MB-231乳腺癌，A-549肺癌和HT-29结肠癌培养的人类癌细胞的细胞毒性。 GI（50）值在微摩尔浓度水平之内和之下。

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《Archiv der Pharmazie》 |2009年第10期|共9页
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Molinari A; Oliva A; Ojeda;
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中图分类药学;
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机译：1,4-萘氢醌-1,4-二乙酸酯的6-（3-吡唑基丙基）衍生物的合成和细胞毒性评估。
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Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate.

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