Synthesis, anticonvulsant, and anti-inflammatory activities of some new benzofuran-based heterocycles.

Dawood KM; Abdel Gawad H; Ellithey M; Mohamed HA; Hegazi B

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Synthesis, anticonvulsant, and anti-inflammatory activities of some new benzofuran-based heterocycles.

机译：一些基于苯并呋喃的新型杂环的合成，抗惊厥和抗炎活性。

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Treatment of 2-bromoacetylbenzofuran (2) with pyridine afforded its corresponding pyridinium bromide 3. The latter salt reacted with some activated alkenes and acetylenes to give the corresponding indolizine derivatives. Treatment of the salt 3 with benzylidenemalononitriles 9 afforded polysubstituted aniline derivatives, however with arylidenecyanothioacetamides 15 it gave the corresponding 4,5-dihydrothiophenes. Bromide 3 also coupled with p-chlorobenzenediazonium salt followed by ammonium acetate to give the corresponding 1,2,4,5-tetrazine derivative. The biological activity of the newly synthesized compounds was examined and some of them were found to possess anticonvulsant and anti-inflammatory activities.

机译：用吡啶处理2-溴乙酰基苯并呋喃（2），得到其相应的吡啶鎓溴化物3。后者的盐与一些活化的烯烃和乙炔反应，得到相应的吲哚嗪衍生物。用亚苄基丙二腈9处理盐3，得到多取代的苯胺衍生物，但是用亚芳基氰基硫代乙酰胺15，它得到相应的4，5-二氢噻吩。溴化物3还与对氯苯重氮盐，然后与乙酸铵偶联，得到相应的1,2,4,5-四嗪衍生物。检查了新合成化合物的生物活性，发现其中一些具有抗惊厥和抗炎活性。

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来源
《Archiv der Pharmazie》 |2006年第3期|共8页
作者
Dawood KM; Abdel Gawad H; Ellithey M; Mohamed HA; Hegazi B;
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正文语种 eng
中图分类药学;
关键词
Anticonvulsants; Benzofurans; 抗惊厥药; 苯呋喃类;

机译：Anticonvulsants;Benzofurans;抗惊厥药;苯呋喃类;

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1. Synthesis, anticonvulsant, and anti-inflammatory activities of some new benzofuran-based heterocycles. [J] . Dawood KM, Abdel Gawad H, Ellithey M, Archiv der Pharmazie . 2006,第3期

机译：一些基于苯并呋喃的新型杂环的合成，抗惊厥和抗炎活性。
2. Synthesis, anticonvulsant, and anti-inflammatory evaluation of some new benzotriazole and benzofuran-based heterocycles. [J] . Dawood KM, Abdel Gawad H, Rageb EA, Bioorganic and Medicinal Chemistry . 2006,第11期

机译：一些新的苯并三唑和苯并呋喃基杂环的合成，抗惊厥和抗炎评估。
3. Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of some new 4,6-dimethoxy-5-(heterocycles)benzofuran starting from naturally occurring visnagin [J] . E.R. El-Sawy, M.S. Ebaid, H.M. Abo-Salem Arabian journal of chemistry . 2014,第6期

机译：一些新的4,6-二甲氧基-5-（杂环）苯并呋喃的合成，消炎，镇痛和抗惊厥活性从天然存在的香精开始
4. Synthesis and In Vitro Anti-inflammatory Activity of Pyrrolo1, 2-apyrazines via Pd-catalyzed Intermolecular Cyclization Reaction [C] . Yanmei Zhou, Yong Wei, Jin Yang, International Conference on Material Engineering, Chemistry, Bioinformatics . 2014

机译：通过PD催化的分子分子化反应的吡咯并1,2-A吡嗪的合成和体外抗炎活性
5. Application of microwave irradiation and solid acid catalysts in environmental organic chemistry. Synthesis and reactivity of heterocycles. [D] . Vazquez Fernandez-Pacheco, Ester. 2000

机译：微波辐射和固体酸催化剂在环境有机化学中的应用。杂环的合成和反应性。
6. An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent Benzocamphorin F and Its Anti-Inflammatory Activity [O] . Yu-Ren Liao, Ping-Chung Kuo, Jun-Weil Liang, 2012

机译：有效的全合成有效的消炎剂苯并樟脑磷脂F及其消炎活性
7. Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of some new 4,6-dimethoxy-5-(heterocycles)benzofuran starting from naturally occurring visnagin [O] . E.R. El-Sawy, M.S. Ebaid, H.M. Abo-Salem, 2014

机译：从天然存在的visnagin开始，一些新的4,6-二甲氧基-5-（杂环）苯并呋喃的合成，抗炎，镇痛和抗惊厥活性

Synthesis, anticonvulsant, and anti-inflammatory activities of some new benzofuran-based heterocycles.

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