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首页> 外文期刊>Archiv der Pharmazie >A study of anti-inflammatory activity of some novel alpha-amino naphthalene and beta-amino naphthalene derivatives.
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A study of anti-inflammatory activity of some novel alpha-amino naphthalene and beta-amino naphthalene derivatives.

机译：某些新型α-氨基萘和β-氨基萘衍生物的抗炎活性研究。

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In the present study, some naphthalene derivatives have been synthesized by incorporating azetidinyl and thiazolidinyl moieties at its alpha- or beta-positions such as alpha-(3-chloro-2-oxo-4-substituted)aryl-1-azetidinyl)naphthalenes 6-10, alpha-((substituted)aryl-4-oxo-1,3-thiazolidin-3-yl)naphthalenes 11-15, beta-(3-chloro-2-oxo-4-substituted aryl-1-azetidinyl)naphthalenes 21-25, and beta-(substituted aryl-4-oxo-1,3-thiazolidin-3-yl)naphthalenes 26-30. These compounds have also been screened for acute toxicity and anti-inflammatory and analgesic activities. Compounds which showed better anti-inflammatory and analgesic activities were also examined for their ulcerogenic liability and underwent a cyclooxygenase assay. Two compounds, 12 and 28, were found to exhibit potent anti-inflammatory activity as compared to the standard drugs phenylbutazone and naproxen.
机译：在本研究中，某些萘衍生物是通过在其α或β位置掺入氮杂环丁烷基和噻唑烷基的部分而合成的，例如α-（3-氯-2-氧代-4-取代的芳基-1-氮杂环丁烷基）萘6 -10，α-（（取代）芳基-4-氧代-1,3-噻唑烷-3-基）萘11-15，β-（3-氯-2-氧代-4-取代芳基-1-氮杂环丁烷基）萘21-25和β-（取代的芳基-4-氧代-1,3-噻唑烷-3-基）萘26-30。还已经筛选了这些化合物的急性毒性以及抗炎和止痛活性。还检查了显示出更好的抗炎和止痛活性的化合物的致溃疡作用，并进行了环氧合酶测定。与标准药物苯基丁a和萘普生相比，发现两种化合物（12和28）具有有效的抗炎活性。

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