Long-chain 3-acyl-4-hydroxycoumarins: structure and antibacterial activity.

Cravotto G; Tagliapietra S; Cappello R; Palmisano G; Curini M; Boccalini M

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Long-chain 3-acyl-4-hydroxycoumarins: structure and antibacterial activity.

机译：长链3-酰基-4-羟基香豆素：结构和抗菌活性。

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By reacting 4-hydroxycoumarin with long-chain acyl chlorides, a number of new 3-acyl derivatives were prepared and the relationship was studied between their structures and activities against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, and Propionibacterium acnes ATCC 11827. Antibacterial activity was associated with enolic tautomers of a tricarbonylmethane group bearing a lipophilic side chain (undec-10-enoyl, undec-10-ynoyl, palmitoyl or octadec-9-enoyl). A newly synthesized 2-acyl derivative of 2H-indene-1,3-dione containing the same tricarbonylmethane motif showed a comparable activity.

机译：通过使4-羟基香豆素与长链酰氯反应，制备了许多新的3-酰基衍生物，并研究了它们的结构与活性对金黄色葡萄球菌ATCC 6538，表皮葡萄球菌ATCC 12228和痤疮丙酸杆菌ATCC 11827的活性之间的关系。活性与带有亲脂性侧链的三羰基甲烷基团的烯醇式互变异构体（十一碳十烯酰基，十一碳十炔基，棕榈酰基或十八碳九烯基）有关。含有相同的三羰基甲烷基序的2H-茚-1,3-二酮的新合成的2-酰基衍生物显示出可比的活性。

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来源
《Archiv der Pharmazie》 |2006年第3期|共4页
作者
Cravotto G; Tagliapietra S; Cappello R; Palmisano G; Curini M; Boccalini M;
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正文语种 eng
中图分类药学;
关键词
4-Hydroxycoumarins; Anti-Bacterial Agents; 4-羟基香豆素类;

机译：4-Hydroxycoumarins;Anti-Bacterial Agents;4-羟基香豆素类;

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1. Long-chain 3-acyl-4-hydroxycoumarins: structure and antibacterial activity. [J] . Cravotto G, Tagliapietra S, Cappello R, Archiv der Pharmazie . 2006,第3期

机译：长链3-酰基-4-羟基香豆素：结构和抗菌活性。
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Long-chain 3-acyl-4-hydroxycoumarins: structure and antibacterial activity.

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