...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archiv der Pharmazie >Synthesis and protective effects of novel salidroside analogues on glucose and serum depletion induced apoptosis in PC12 cells
【24h】

Synthesis and protective effects of novel salidroside analogues on glucose and serum depletion induced apoptosis in PC12 cells

机译：红景天苷类似物的合成及其对葡萄糖和血清耗竭诱导的PC12细胞凋亡的保护作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Salidroside is a natural product isolated from Rhodiola rosea L. which possesses a wide range of biological activities, especially neuroprotective effects in the treatment of ischemic stroke. In an attempt to improve its neuroprotective effects, a series of novel salidroside analogues were synthesized and their neuroprotective activities were evaluated against the glucose and serum depletion-induced cell death in differentiated PC12 cells. Most target compounds displayed protective effects on the cell viability, especially for compound 6, which had a great potency superior to salidroside. MTT assay and Hoechst 33342 staining collectively showed that pretreatment with 6 attenuated cell viability loss and reduced apoptotic death in cultured PC12 cells with glucose and serum depletion. And its neuroprotective effects might be associated with the increase of the apoptosis-related protein Bcl-2/Bax expression ratio, and also with the inhibition of caspase-3 activation. Therefore, our new findings may provide potentially important information for further development of salidroside analogues and lay the basis for further studies on the cerebral ischemic stroke and neurodegenerative diseases for human clinical treatment. A series of novel salidroside analogues were synthesized and their neuroprotective activities were evaluated against the glucose and serum depletion-induced cell death in differentiated PC12 cells. Most target compounds displayed protective effects. Compound 6, which had great potency superior to salidroside, attenuated cell viability loss and reduced apoptotic death in cultured PC12 cells. Its neuroprotective effects may be associated with an increased apoptosis-related Bcl-2/Bax protein expression ratio and inhibition of caspase-3 activation.
机译：红景天苷是从玫瑰红景天中分离得到的天然产物，具有广泛的生物学活性，尤其是在缺血性中风的治疗中具有神经保护作用。为了改善其神经保护作用，合成了一系列新的红景天苷类似物，并评估了它们对分化的PC12细胞中葡萄糖和血清耗竭诱导的细胞死亡的神经保护活性。大多数目标化合物对细胞活力都显示出保护作用，尤其是对化合物6而言，它的功效强于红景天苷。 MTT测定法和Hoechst 33342染色共同显示在葡萄糖和血清消耗下，培养的PC12细胞中6种预处理可减弱细胞活力，并减少其凋亡死亡。其神经保护作用可能与凋亡相关蛋白Bcl-2 / Bax表达比的增加有关，也可能与对caspase-3激活的抑制有关。因此，我们的新发现可能为红景天苷类似物的进一步开发提供潜在的重要信息，并为进一步研究脑缺血性中风和神经退行性疾病为人类临床治疗奠定基础。合成了一系列新颖的红景天苷类似物，并评估了它们对分化的PC12细胞中葡萄糖和血清耗竭诱导的细胞死亡的神经保护活性。大多数目标化合物均显示出保护作用。化合物6具有比红景天苷更强的效力，可减轻细胞活力丧失，并减少培养的PC12细胞的凋亡死亡。它的神经保护作用可能与凋亡相关的Bcl-2 / Bax蛋白表达比增加和caspase-3激活抑制有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号