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首页> 外文期刊>American journal of medical genetics, Part A >Adaptive behavior in adolescents and adults with Down syndrome: Results from a 6-month longitudinal study
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Adaptive behavior in adolescents and adults with Down syndrome: Results from a 6-month longitudinal study

机译：患有唐氏综合征的青少年和成年人的自适应行为：6个月的纵向研究结果

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Measures of adaptive behavior are important in the assessment and treatment of individuals with intellectual disabilities (ID). The purpose of the current study was to evaluate the stability of an established and a novel measure of adaptive behavior over time, and their suitability as outcome measures in clinical trials targeting individuals with Down syndrome (DS). This 6-month, longitudinal, noninterventional, multinational study included adolescents (12-17 years) and adults (18-30 years) with DS. Participants were from seven countries (11 different sites) with English, Spanish and French as their native language. The Vineland Adaptive Behavior Scales-II (VABS-II) and a newly developed Clinician Global Impression (CGI) scale were administered at baseline, 1 and 6 months. Adults had lower composite standard scores on all domains of the VABS-II compared with adolescents. The communication domain was a weakness relative to the socialization and daily living skills domains on the VABS-II and the CGI-Severity scale. These findings were stable over 6 months, as exhibited by high intraclass correlations (0.75). These results provide valuable baseline data for use in trial design and endpoint selection for studies including individuals with DS. ClinicalTrials.gov identifier: NCT01580384.
机译：自适应行为的措施对于具有智力障碍（ID）的个人的评估和待遇是重要的。目前研究的目的是评估建立的和新的适应性程度的稳定性随着时间的推移，它们作为临床试验中的结果措施的适用性，靶向综合征（DS）的临床试验。今年6个月，纵向，非行动，跨国公司研究包括青少年（12-17岁）和DS的成年人（18-30岁）。参与者来自七个国家（11个不同的网站），英语，西班牙语和法语作为他们的母语。 Vineland自适应行为秤-II（VABS-II）和新开发的临床医生全球印象（CGI）规模在基线，1和6个月内施用。与青少年相比，成年人在VABS-II的所有域上具有较低的复合标准分数。通信领域相对于VABS-II的社会化和日常生活技能域以及CGI - 严重程度规模是一种弱点。这些发现超过6个月稳定，如高脑内相关性（＆ 0.75）所展示。这些结果提供了有价值的基线数据，用于试验设计和终点选择的研究，包括DS的个人。 ClinicalTrials.gov标识符：NCT01580384。

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