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首页> 外文期刊>Journal of Biotechnology >Plant cell-based processes for cyclotides production
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Plant cell-based processes for cyclotides production

机译：基于植物细胞的环肽生产工艺

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摘要

Cyclotides are naturally occurring mini-proteins that have a diverse range of therapeutically useful biological activities. Although a choice of approaches is available for cyclotides synthesis; most studies have involved the use of peptides extracted from plants. In order to facilitate the screening for structure-activity studies or to exploit them in drug development, a convenient and reliable route for the biosynthesis of cyclotides is of vital importance. Callus, suspension cultures and hydroponic plants of Oldenlandia affinis were established and have been evaluated for effective cyclotides production processes. The specific accumulation of kalata B1 was affected by cell differentiation as well as agitation; highest accumulation of 2.7mggu-u1 dry weight was detected in agitated hydroponic plant cultures resulting in a productivity of 1.4mgkalataB1lu-u1dayu-u1.
机译：环肽是天然存在的小蛋白，具有多种治疗上有用的生物学活性。尽管有多种方法可用于环氧化物的合成;大多数研究涉及使用从植物中提取的肽。为了促进对结构活性研究的筛选或将其用于药物开发，一种简便且可靠的生物合成环氧化物的途径至关重要。建立了Oldenlandia affinis的愈伤组织，悬浮培养物和水培植物，并对其有效的环氧化物生产过程进行了评估。 kalata B1的特异性积累受细胞分化和搅拌的影响;在搅拌的水培植物培养物中检测到最高的2.7mggu-u1干重积累，从而产生了1.4mgkalataB1lu-u1dayu-u1的生产力。

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