Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics

Basnet DB; Park JW; Yoon YJ

首页> 外文期刊>Journal of Biotechnology >Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics

【24h】

Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics

机译：5-O-去甲磺胺基赤藓醇内酯A的组合生物合成，是酮内酯抗生素的强效前体

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Ketolides, characterized by possessing a 3-keto group in place of the l-cladinose moiety of erythromycin A, are the recent generation of antimicrobials derived semi-synthetically from the 14-membered ring macrolide erythromycin A. The multi-step synthetic route to ketolides can be shortened by using 5-O-desosaminyl erythronolide A as a precursor, which reduces the steps for the removal of l-cladinose attached at the C-3 position in erythromycin A. Deletion of an eryBV gene encoding mycarosyl glycosyltransferase in the erythromycin-producer Saccharopolyspora erythraea resulted in the accumulation of 5-O-desosaminyl erythronolide B. In vivo expression of the cytochrome P450 gene pikC, which encodes the substrate-flexible hydroxylase from the pikromycin biosynthetic pathway of Streptomyces venezuelae, in the eryBV deletion mutant strain of Sac. erythraea led to 5-O-desosaminyl erythronolide A production.

机译：酮内酯的特征是具有3-酮基团代替红霉素A的l-cladinose部分，是新一代的由14元环大环内酯类红霉素A半合成衍生的抗菌剂。可以通过使用5-O-去甲磺酰基赤藓醇内酯A作为前体来缩短，这减少了去除附着在红霉素A C-3位上的1-cladinose的步骤。在红霉素-中缺失编码霉菌糖基糖基转移酶的eryBV基因生产者赤霉菌多孢菌导致5-O-去甲磺酰基赤藓醇内酯B的积累。细胞色素P450基因pikC的体内表达编码Sac的eryBV缺失突变株中委内瑞拉链霉菌生物合成途径的底物柔性羟化酶。。红斑导致产生了5-O-去甲磺酰基赤藓醇内酯A。

著录项

来源
《Journal of Biotechnology》 |2008年第1期|共5页
作者
Basnet DB; Park JW; Yoon YJ;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
关键词
Cytochrome P450; Deletion mutant; Erythromycin; Cytochrome P450; Deletion mutant; Erythromycin; Gene deletion; Glycosyltransferase; Hydroxylase; ketolide antibiotics; Saccharopolyspora erythraea; Streptomyces venezuelae;

机译：细胞色素P450;缺失突变体;红霉素;细胞色素P450;缺失突变体;红霉素;基因缺失;糖基转移酶;羟化酶;酮内酯抗生素;糖多孢菌;红斑链霉;

相似文献

外文文献
中文文献
专利

1. Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics [J] . Basnet DB, Park JW, Yoon YJ Journal of Biotechnology . 2008,第1期

机译：5-O-去甲磺胺基赤藓醇内酯A的组合生物合成，是酮内酯抗生素的强效前体
2. Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. [J] . Liang CH, Yao S, Chiu YH, Bioorganic and Medicinal Chemistry Letters . 2005,第5期

机译：新型5-O-糖修饰的酮内酯和2-氟代酮内酯抗生素的合成及生物活性。
3. Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics. [J] . Henninger TC, Xu X, Abbanat D, Bioorganic and Medicinal Chemistry Letters . 2004,第17期

机译：C-6氨基甲酸酯酮化物（一种新型口服活性酮类抗生素）的合成和抗菌活性。
4. Biosynthesis of Siderophore-Peptides, A Class of Potent Antimicrobial Peptides from Enterobacteria, Requires Two Precursors [C] . Gaelle Vassiliadis, Jean Peduzzi, Delphine Destoumieux-Garzon American Peptide Symposium . 2009

机译：生物合成的绵延肽，一类来自细菌的一类有效的抗微生物肽需要两体前体
5. Combinatorial biosynthesis of polyketides: Oxygenases in angucycline antibiotic biosynthesis. [D] . Rix, Uwe. 2003

机译：聚酮化合物的组合生物合成：安古环素抗生素生物合成中的加氧酶。
6. Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides [O] . Mashal M. Almutairi, Sung Ryeol Park, Simon Rose, 2015

机译：在天然酮醇化物的细菌生产者中通过rRNA甲基转移酶的协同表达对酮醚类抗生素具有耐药性
7. Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity [O] . Wiedemann No Value, Breukink E, van Kraaij C, 2001

机译：乳链菌肽与肽聚糖前体脂质II的特异性结合结合了孔的形成和对细胞壁生物合成的抑制作用，从而具有强大的抗生素活性

Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics

摘要

著录项

相似文献

相关主题

期刊订阅