An efficient and cost-effective approach to kahalalide F N-terminal modifications using a nuisance algal bloom of Bryopsis pennata

Wang Bin; Waters Amanda L.; Valeriote Frederick A.; Hamann Mark T.

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An efficient and cost-effective approach to kahalalide F N-terminal modifications using a nuisance algal bloom of Bryopsis pennata

机译：一种高效且经济有效的方法，利用Bryopsis pennata的滋生藻华来进行Kahalalide F N末端修饰

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Background: Kahalalide F (KF) and its isomer iso-kahalalide F (isoKF), both of which can be isolated from the mollusk Elysia rufescens and its diet alga Bryopsis pennata, are potent cytotoxic agents that have advanced through five clinical trials. Due to a short half-life, narrow spectrum of activity, and a modest response in patients, further efforts to modify the molecule are required to address its limitations. In addition, due to the high cost in producing KF analogues using solid phase peptide synthesis (SPPS), a degradation and reconstruction approach was employed using natural KF from a seasonal algal bloom to generate KF analogues.

机译：背景：可以从软体动物Elysia rufescens及其饮食藻类Bryopsis pennata中分离得到的Kahalalide F（KF）及其异构体iso-kahalalide F（isoKF）是有效的细胞毒性药物，已通过五项临床试验进行了研究。由于半衰期短，活性谱窄以及患者反应中等，因此需要进一步努力修饰该分子以解决其局限性。此外，由于使用固相肽合成（SPPS）生产KF类似物的成本较高，因此采用了从季节性藻华中提取天然KF的降解和重建方法来生成KF类似物。

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《Biochimica et Biophysica Acta. General Subjects》 |2015年第9期|共6页
作者
Wang Bin; Waters Amanda L.; Valeriote Frederick A.; Hamann Mark T.;
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正文语种 eng
中图分类生物化学;
关键词
Kahalalide F; Partial hydrolysis; N-terminal modification;

机译：Kahalalide F;部分水解;N-末端修饰;
入库时间 2022-08-18 09:01:40

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1. An efficient and cost-effective approach to kahalalide F N-terminal modifications using a nuisance algal bloom of Bryopsis pennata [J] . Wang Bin, Waters Amanda L., Valeriote Frederick A., Biochimica et Biophysica Acta. General Subjects . 2015,第9期

机译：一种高效且经济有效的方法，利用Bryopsis pennata的滋生藻华来进行Kahalalide F N末端修饰
2. An adaptive approach to detect high-biomass algal blooms from EO chlorophyll-a data in support of harmful algal bloom monitoring [J] . JAMIE D. SHUTLER, KEITH DAVIDSON, PETER I. MILLER, Remote sensing letters . 2012,第2期

机译：一种从EO叶绿素a数据检测高生物量藻华的自适应方法，以支持有害藻华监测
3. Feeding behaviour of a serpulid polychaete: Turning a nuisance species into a natural resource to counter algal blooms? [J] . Leung Jonathan Y. S., Cheung Napo K. M. Marine pollution bulletin . 2017,第1a2期

机译：Serpulid多毛羚的进食行为：将令人讨厌的物种转变为天然资源以对抗藻华？
4. Spectral Modeling for the Identification and Ouantification of Algal Blooms: A Test of Approach [C] . Tim J. Malthus, Laura Grieve, Martin D. Harwar International conference on remote sensing for marine and coastal environments . 1997

机译：光谱识别和藻华化的光谱模型：方法检验
5. A microbiomic approach to the characterization of the impacts and influences of viral, bacterial, and harmful algal bloom toxins on the bottlenose dolphin. [D] . Russo, Corey David. 2016

机译：微生物学方法，用于表征病毒，细菌和有害藻华毒素对宽吻海豚的影响。
6. An Efficient and Cost-effective Approach to Kahalalide F N-terminal Modifications using a Nuisance Algal Bloom of Bryopsis pennata [O] . Bin Wang, Amanda L. Waters, Fred Valeriote, -1

机译：一种高效低成本高效率的方法使用Bryopsis pennata的滋生藻华对Kahalalide F N末端进行修饰
7. An efficient and cost-effective approach to kahalalide F N-terminal modifications using a nuisance algal bloom of Bryopsis pennata [O] . Bin Wang, Amanda L. Waters, Frederick A. Valeriote, 2015

机译：使用Bryopsis Pennata的滋扰藻类盛开的Kahalalide F N末端修饰的高效且经济有效的方法
8. Potential for Eutrophication and Nuisance Algal Blooms in the Lower Neuse River Estuary [R] . Paerl, H. W., Mallin, M., Rudek, J., 1990

机译：下河岸河口富营养化和滋扰藻类的可能性

An efficient and cost-effective approach to kahalalide F N-terminal modifications using a nuisance algal bloom of Bryopsis pennata

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