Special Issue: Cell Biology of Cancer Balancing the innate immune system in tumor development

Hagerling Catharina; Casbon Amy-Jo; Werb Zena

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Special Issue: Cell Biology of Cancer Balancing the innate immune system in tumor development

机译：特刊：癌症的细胞生物学平衡肿瘤发展中的先天免疫系统

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Cells of the innate immune system have a dual role in cancer development in both tumor initiation and progression. Innate immune cells can, on the one hand, aid malignant transformation and tumor outgrowth and, on the other hand, prevent tumor progression. The innate immune system has the ability to tune the inflammatory response and is a key player in cancer-related inflammation, which can precede the development of malignancy or be induced by oncogenic changes promoting a protumor inflammatory milieu. In this review, we discuss the emerging cellular and molecular mechanisms of the innate immune system and inflammation in tumor initiation and progression, and point to the outstanding questions that remain.

机译：先天免疫系统的细胞在肿瘤的发生和发展中对癌症的发展具有双重作用。先天性免疫细胞一方面可以帮助恶性转化和肿瘤生长，另一方面可以防止肿瘤进展。先天性免疫系统具有调节炎症反应的能力，并且是癌症相关炎症的关键因素，其可以在恶性肿瘤发生之前发生，或者由促进原发性炎症环境的致癌变化诱导。在这篇综述中，我们讨论了先天免疫系统和炎症在肿瘤发生和发展中的新兴细胞和分子机制，并指出了仍然存在的悬而未决的问题。

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《Trends in Cell Biology》 |2015年第4期|共7页
作者
Hagerling Catharina; Casbon Amy-Jo; Werb Zena;
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正文语种 eng
中图分类 Q28;
关键词
innate immune cells; inflammation; cancer development;

机译：先天免疫细胞;炎症;癌症发展;

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1. Special Issue: Cell Biology of Cancer Balancing the innate immune system in tumor development [J] . Hagerling Catharina, Casbon Amy-Jo, Werb Zena Trends in Cell Biology . 2015,第4期

机译：特刊：癌症的细胞生物学平衡肿瘤发展中的先天免疫系统
2. Pattern recognition receptors acting in innate immune system of shrimp against pathogen infections. (Special Issue: Innate immune system of shrimp.) [J] . Wang XianWei, Wang JinXing Fish & Shellfish Immunology . 2013,第4期

机译：模式识别受体在虾的天然免疫系统中抵抗病原体感染。（特刊：虾的先天免疫系统。）
3. Reprint of: virus-binding proteins and their roles in shrimp innate immunity. (Special Issue: Innate immune system of shrimp.) [J] . Sritunyalucksana K., Utairungsee T., Sirikharin R., Fish & Shellfish Immunology . 2013,第4期

机译：转载：病毒结合蛋白及其在虾固有免疫中的作用。（特刊：虾的先天免疫系统。）
4. The cell biology of the innate immune response to Aspergillus fumigatus [C] . Michael K. Mansour, Jenny M. Tam, Jatin M. Vyas Advances Against Aspergillosis Conference . 2012

机译：对叶绿体菌的先天免疫反应的细胞生物学
5. Transitional 2 B cells function as a pivotal stage in peripheral B lymphocyte development: Implications for selection, innate vs. adaptive immunity, and cancer biology. [D] . Su, Thomas. 2002

机译：过渡性2 B细胞在外周B淋巴细胞发育中起关键作用：对选择，先天性与适应性免疫以及癌症生物学的影响。
6. Will Systems Biology Deliver Its Promise and Contribute to the Development of New or Improved Vaccines?: Systems Biology Views of Vaccine Innate and Adaptive Immunity [O] . Rino Rappuoli, Emilio Siena, Oretta Finco 2018

机译：系统生物学将提供其承诺并有助于开发新的或改进的疫苗吗？：系统生物学视图对疫苗先天和自适应免疫力
7. Balancing the innate immune system in tumor development [O] . Catharina Hagerling, Amy-Jo Casbon, Zena Werb 2015

机译：平衡肿瘤发展中的天生免疫系统

Special Issue: Cell Biology of Cancer Balancing the innate immune system in tumor development

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