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首页> 外文期刊>Trends in Cell Biology >The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development
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The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

机译：14-3-3蛋白：影响细胞命运和癌症发展的各种信号提示的整合者

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摘要

The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phosphoserine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phosphoregulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis.
机译：由于高度保守的14-3-3蛋白家族参与重要的细胞过程，例如新陈代谢，蛋白运输，信号转导，细胞凋亡和细胞周期调控，因此在细胞生物学中已占据重要地位。 14-3-3蛋白是与多种结合伴侣相互作用的磷酸丝氨酸/磷酸苏氨酸结合蛋白。由于许多14-3-3相互作用是磷酸化依赖性的，因此14-3-3已紧密整合到核心的磷酸调节途径中，这对于正常的生长和发育至关重要，并且在人类疾病（例如癌症）中常常失调。这篇综述检查了最近的进展，这些进展进一步阐明了14-3-3蛋白作为影响细胞命运决定和肿瘤发生的各种信号提示的整合者的作用。

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