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首页> 外文期刊>Trends in Cell Biology >The role of profilin complexes in cell motility and other cellular processes [Review]
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The role of profilin complexes in cell motility and other cellular processes [Review]

机译:脯氨酸蛋白复合物在细胞运动和其他细胞过程中的作用[综述]

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摘要

Profilins are small actin-binding proteins that are essential in all organisms that have been examined to date. In vitro, profilins regulate the dynamics of actin polymerization, which is their key role in vivo during cell motility. However, there is growing evidence that, apart from actin binding, profilins function as hubs that control a complex network of molecular interactions. Profilins interact with a plethora of proteins and the importance of this aspect of their function is just beginning to be understood. In this article, I will summarize recent findings in mammalian cells and mice, and discuss the evidence of a role for profilins in cellular processes such as membrane trafficking, small-GTPase signaling and nuclear activities, in addition to neurological diseases and tumor formation. [References: 81]
机译:脯氨酸蛋白是小的肌动蛋白结合蛋白,是迄今为止已检查过的所有生物必不可少的蛋白。在体外,脯氨酸蛋白调节肌动蛋白聚合的动力学,这是它们在细胞运动期间在体内的关键作用。但是,越来越多的证据表明,除肌动蛋白结合外,蛋白水解酶还充当控制复杂分子相互作用网络的枢纽。脯蛋白与大量蛋白质相互作用,其功能这一方面的重要性才刚刚开始被理解。在这篇文章中,我将总结哺乳动物细胞和小鼠的最新发现,并讨论蛋白原在神经系统疾病和肿瘤形成以及细胞膜运输,小GTPase信号传导和核活动等细胞过程中的作用的证据。 [参考:81]

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