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首页> 外文期刊>Trends in Cell Biology >Regulating the clathrin-coated vesicle cycle by AP2 subunit phosphorylation
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Regulating the clathrin-coated vesicle cycle by AP2 subunit phosphorylation

机译：通过AP2亚基磷酸化调节网格蛋白包被的囊泡周期

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摘要

Clathrin-coated pits form from the concerted assembly of many different protein components that interact with each other and with the lipid bilayer. When the coated pit pinches off to form a coated vesicle, the coat is removed to allow fusion of the endocytic vesicle with an early endosome, and the disassembled coat components can then recycle through the cytosol to participate in new rounds of coated pit formation. One potential mechanism to regulate the cycles of coat protein assembly and disassembly is reversible phosphorylation, particularly given that many of the coat components, such as the AP2 adaptor complex, are phosphorylated on multiple sites both in vitro and in vivo. Recent studies have provided particular insight into the role of phosphorylation of the cargo-binding p2 subunit of AP2.
机译：网格蛋白包被的凹坑是由许多相互之间以及与脂质双层相互作用的不同蛋白质组分的协同组装形成的。当包被的小窝捏开形成包被的囊泡时，去除包衣以使内吞囊泡与早期的内体融合，然后分解的包被成分可循环通过细胞溶质，参与新一轮的包被的窝形成。调节外壳蛋白组装和拆卸循环的一种潜在机制是可逆的磷酸化，特别是考虑到许多外壳组分（例如AP2衔接子复合物）在体外和体内都在多个位点被磷酸化。最近的研究对AP2的货物绑定p2亚基的磷酸化作用提供了特别的见识。

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