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首页> 外文期刊>Trends in Cell Biology >Multivesicular bodies: a mechanism to package lytic and storage functions in one organelle?
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Multivesicular bodies: a mechanism to package lytic and storage functions in one organelle?

机译：多囊泡体：将裂解和储存功能包装在一个细胞器中的一种机制？

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摘要

Multivesicular bodies (MVBs) are endosomes or prevacuolar compartments. The lumens of their internal vesicles are thought to be topologically equivalent to cytoplasm and their membranes direct proteins and lipids for degradation. Here, we describe a new MVB function; in certain plant MVBs, the internal vesicles contain lytic enzymes and the surrounding 'soup' is a storage compartment. Separate vesicular pathways deliver proteins to the storage and lytic compartments. Recent data indicate that mammalian secretory lysosomes also have two compartments served by separate vesicular pathways. The formation of separate storage and lytic compartments within MVBs poses problems for membrane organization and topology that have not previously been considered in the literature. We offer a hypothetical model to address these problems.
机译：多囊泡体（MVB）是内体或前室。人们认为其内部囊泡的内腔在拓扑学上等同于细胞质，并且它们的膜引导蛋白质和脂质降解。在这里，我们描述了一个新的MVB功能;在某些植物MVB中，内部囊泡中含有分解酶，周围的“汤”是一个储藏室。分开的囊泡途径将蛋白质递送至储存室和裂解室。最近的数据表明，哺乳动物的分泌性溶酶体也有两个由分开的囊泡途径提供服务的区室。 MVB内分开的储存室和裂解室的形成给膜的组织和拓扑带来了问题，这在文献中以前没有考虑过。我们提供了一个假设模型来解决这些问题。

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