Altered trafficking and epithelial cell polarity in disease [Review]

Stein MP; Wandinger-Ness A; Roitbak T

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Altered trafficking and epithelial cell polarity in disease [Review]

机译：疾病中运输和上皮细胞极性改变[综述]

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Establishment and maintenance of a polarized epithelium relies on the integration of signaling cascades, acquisition of specialized trafficking circuits and establishment of a unique cytoarchitecture. Defects in any of these processes can adversely affect cell polarity and cause defects in specific organs and systemic disease. Mutations that disrupt the proper transport of individual plasma membrane proteins, or inactivate components of the epithelial-specific trafficking machinery, have severe functional consequences. Links between renal diseases and defects in trafficking, differentiation or signaling, highlight the delicate balance between these parameters which, when altered, [References: 94]

机译：极化上皮细胞的建立和维持依赖于信号级联的整合，获得专门的运输回路以及建立独特的细胞结构。这些过程中的任何一个缺陷都会对细胞极性产生不利影响，并导致特定器官和全身性疾病的缺陷。破坏单个质膜蛋白的正确运输或使上皮特异性运输工具的成分失活的突变具有严重的功能后果。肾脏疾病与运输，分化或信号传导缺陷之间的联系突显了这些参数之间的微妙平衡，这些参数在被改变时[参考文献：94]

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《Trends in Cell Biology》 |2002年第8期|共8页
作者
Stein MP; Wandinger-Ness A; Roitbak T;
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正文语种 eng
中图分类细胞生物学;
关键词
Polycystic kidney-disease; Microvillus inclusion disease; Border; membrane-protein; Trans-golgi network; Ldl receptor gene; Plasma-membrane; Familial hypercholesterolemia; Apical membrane; Renal; epithelia; Mdck cells;

机译：多囊肾疾病;微绒毛膜包涵体疾病;边界;膜蛋白;反-高尔基体网络;Ldl受体基因;血浆膜;家族性高胆固醇血症;顶膜;肾;上皮细胞;Mdck细胞;

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1. Altered trafficking and epithelial cell polarity in disease [Review] [J] . Stein MP, Wandinger-Ness A, Roitbak T Trends in Cell Biology . 2002,第8期

机译：疾病中运输和上皮细胞极性改变[综述]
2. Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells [J] . Rashmi Mishra, Michal Grzybek, Toshiro Niki, Proceedings of the National Academy of Sciences of the United States of America . 2010,第41期

机译：Galectin-9转运调节Madin-Darby犬肾脏上皮细胞的顶基极极性
3. Establishment of plasma membrane polarity in mammary epithelial cells correlates with changes in prolactin trafficking and in annexin VI recruitment to membranes [J] . Francoise Lavialle, Dominique Rainteau, Dominique Massey-Harroche, Biochimica et biophysica acta. Biomembranes . 2000,第1期

机译：乳腺上皮细胞质膜极性的建立与催乳素运输和膜联蛋白VI募集的变化有关
4. Visualizing Protein Trafficking: Membrane Proteins Follow Multiple Trafficking Pathways to the Basolateral Cell Surface in Polarized Epithelial Cells [C] . G.A. Farr, M. Hull, D. Santana Alves, Microscopy and microanalysis.;Microscopy and microanalysis. . -1

机译：可视化蛋白质贩运：膜蛋白遵循极化上皮细胞中基底外侧细胞表面的多种贩运途径。
5. Trafficking and cell surface stability of the epithelial sodium ion channel expressed in epithelial MDCK cells. [D] . Hanwell, David Grant. 2003

机译：在上皮MDCK细胞中表达的上皮钠离子通道的运输和细胞表面稳定性。
6. Galectin-9 trafficking regulates apical-basal polarity in Madin–Darby canine kidney epithelial cells [O] . Rashmi Mishra, Michal Grzybek, Toshiro Niki, 2010

机译：Galectin-9转运调节Madin-Darby犬肾上皮细胞的顶基极极性
7. Galectin-9 trafficking regulates apical-basal polarity in Madin–Darby canine kidney epithelial cells [O] . Mishra, Rashmi, Grzybek, Michal, Niki, Toshiro, 2010

机译：Galectin-9转运调节Madin-Darby犬肾上皮细胞的顶基极极性

Altered trafficking and epithelial cell polarity in disease [Review]

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