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首页> 外文期刊>Trends in Cell Biology >Two-way traffic on the road to plasma membrane repair
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Two-way traffic on the road to plasma membrane repair

机译：质膜修复之路上的双向交通

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摘要

Ca2+ influx through plasma membrane wounds triggers a rapid-repair response that is essential for cell survival. Earlier studies showed that repair requires the exocytosis of intracellular vesicles. Exocytosis was thought to promote resealing by 'patching' the plasma membrane lesion or by facilitating bilayer restoration through reduction in membrane tension. However, cells also rapidly repair lesions created by pore-forming proteins, a form of injury that cannot be resealed solely by exocytosis. Recent studies indicate that, in cells injured by pores or mechanical abrasions, exocytosis is followed by lesion removal through endocytosis. Describing the relationship between wound-induced exocytosis and endocytosis has implications for the understanding of muscular degenerative diseases that are associated with defects in plasma membrane repair.
机译：通过质膜伤口流入的Ca2 +触发快速修复反应，这对于细胞存活至关重要。早期的研究表明，修复需要胞内小泡的胞吐作用。据认为胞吐作用通过“修补”质膜损伤或通过降低膜张力促进双层恢复而促进再密封。然而，细胞还可以迅速修复由成孔蛋白产生的损伤，这种损伤是不能仅通过胞吐作用重新密封的一种损伤形式。最近的研究表明，在被毛孔或机械擦伤损伤的细胞中，胞吐作用随后是通过胞吞作用清除病灶。描述伤口诱导的胞吐作用与胞吞作用之间的关系对于理解与质膜修复缺陷有关的肌肉变性疾病具有重要意义。

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