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首页> 外文期刊>The European physical journal, E. Soft matter >Multicellular aggregates: A model system for tissue rheology
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Multicellular aggregates: A model system for tissue rheology

机译：多细胞聚集体：组织流变学的模型系统

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Morphogenetic processes involve cell flows. The mechanical response of a tissue to active forces is linked to its effective viscosity. In order to decouple this mechanical response from the complex genetic changes occurring in a developing organism, we perform rheometry experiments on multicellular aggregates, which are good models for tissues. We observe a cell softening behavior when submitting to stresses. As our technique is very sensitive, we were able to get access to the measurement of a yield point above which a creep regime is observed obtained for strains above 12%. To explain our rheological curves we propose a model for the cytoskeleton that we represent as a dynamic network of parallel springs, which will break under stress and reattach at null strain. Such a simple model is able to reproduce most of the important behavior of cells under strain. We highlight here the importance of considering cells as complex fluids whose properties will vary with time according to the history of applied stress. Graphical abstract: [Figure not available: see fulltext.]
机译：形态发生过程涉及细胞流动。组织对作用力的机械响应与其有效粘度有关。为了使这种机械反应与发育中的生物中发生的复杂遗传变化脱钩，我们对多细胞聚集体进行了流变学实验，这是组织的良好模型。当我们承受压力时，我们观察到细胞软化行为。由于我们的技术非常敏感，因此我们能够获得屈服点的测量值，在该屈服点以上，对于高于12％的应变，可以观察到蠕变状态。为了解释我们的流变曲线，我们提出了一个细胞骨架模型，我们将其表示为平行弹簧的动态网络，该网络将在应力作用下断裂并在零应变时重新附着。这种简单的模型能够重现细胞在应变下的大多数重要行为。我们在此强调将细胞视为复杂流体的重要性，这些流体的性质会根据施加应力的历史而随时间变化。图形摘要：[该图不可用：请参见全文。]

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