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A 13-year real-life study on efficacy safety and biological effects of Vespula venom immunotherapy

机译:一项为期13年的真实生活研究研究维斯普拉毒液免疫疗法的功效安全性和生物学效应

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摘要

BackgroundHymenoptera venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account for VIT efficacy, including reduction of specific IgE and induction of allergen-specific IgG4, but the overall picture remains elusive. We investigated Vespula VIT clinical efficacy up to 8 years after discontinuation and the kinetics of Vespula-specific IgE and IgG4. Out of 686 consecutive patients we retrospectively selected and analysed a series of 23 patients with Vespula allergy that underwent a 5-year IT course, followed by a prolonged follow-up.
机译:背景膜翅目毒液免疫治疗(VIT)是一种临床有效的治疗方法。但是,对其长期临床疗效和生物学作用知之甚少。已经提出了几种机制来说明VIT的功效,包括降低特异性IgE和诱导过敏原特异性IgG4,但总体情况仍然难以捉摸。我们研究了停药后长达8年的Vespula VIT临床疗效以及Vespula特异性IgE和IgG4的动力学。在686例连续患者中,我们回顾性选择并分析了23例接受5年IT疗程的Vespula过敏患者,然后进行了长期随访。

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