目的 研究中青年体检人群生理血清尿酸水平与肾小球率过滤的相关性,探讨生理尿酸水平升高对肾功能下降的预测作用.方法 采用横断面调查方法,调查克拉玛依市社区体检人群6 532例和新疆医科大学第一附属医院体检人群2 402例,对研究对象进行问卷调查获取人口学资料,检测血液以及肝、肾功能生化指标；同时采用前瞻性队列研究方法,选择2008年新疆医科大学第一附属医院中青年肾功能正常健康体检人群752例,随访3年后其发生肾功能下降情况及影响因素.结果 在横断面调查中,生理血清尿酸水平均稳定成为肾小球滤过率下降的独立危险因素.按性别、年龄进行分层后,两组人群中除了第1组45岁以上女性人群外,其余各组人群生理血清尿酸均为估计肾小球滤过率(eGFR)下降的危险因素.队列研究中,通过随访3年后肾功能下降的发生率为15.40％,生理血清尿酸水平为肾小球滤过率下降的独立危险因素.结论 生理水平尿酸升高与肾脏功能下降密切相关且对早期肾功能下降具有预测价值.%Objective To investigate the association of serum uric acid level with glomerular filtration rate and explore the predictive value of the physiological uric acid levels for reduced renal function.Methods A total of 6 532 subjects from Karemary community and 2 402 subjects from the First Affiliated Hospital of Xinjiang Medical University were enrolled.All subjects were surveyed with questionnaire and their serum biochemical indices and liver functions were measured.Meanwhile,a cohort study was conducted,752 subjects with normal renal function were selected from young and middle-aged healthy people in 2008.During the 3-year follow-up,the incidence of reduced renal function and the risk factors of estimated glomerular filtration rate (eGFR) were analyzed.Results Serum uric acid (SUA) was the independent risk factor of reduced GFR in cross-sectional analysis.The 2 groups were stratified by sex and age,except for female population over 45 years old in the first group,the level of physiological serum uric acid was the risk factor for decreased eGFR in the rest of groups.During 3-year follow-up,the incidence of reduced renal function was 15.40％ and SUA was the independent risk factor of decreased eGFR.Conclusions The concentration of physiological serum uric acid was closely related with renal function,and the increase in SUA whthin normal range had an important early predictive value for decreased GFR.
展开▼
