首页> 外国专利> COMPLEXES OF IRON (III) FOR TREATING AND PREVENTING IRON DEFICIENCY SYMPTOMS AND IRON DEFICIENCY ANAEMIA

COMPLEXES OF IRON (III) FOR TREATING AND PREVENTING IRON DEFICIENCY SYMPTOMS AND IRON DEFICIENCY ANAEMIA

机译：铁（III）的络合物，用于治疗和预防铁缺乏症和铁缺乏症贫血

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FIELD: chemistry.;SUBSTANCE: present invention relates to complex iron compound (III). Compound contains at least one ligand of formula (I): , where arrows denote coordination connection with one or different iron atoms, R₁ is selected from group consisting of linear or branched C_1-8-alkyl, which can be substituted with C_1-6-alkoxy (RO-), where R denotes unsubstituted alkyl, or C_1-8-alkoxycarbonyl (RO-CO-), where R denotes unsubstituted alkyl; R₂ is selected from group consisting of hydrogen atom, unsubstituted C_1-8-alkyl, halogen atoms and cyano group, or R₁ and R₂, together with carbon atoms with which they are bonded form unsubstituted 5- or 6-member ring, R₃ and R₄ are respectively selected from group consisting of hydrogen atoms, morpholinyl, C_3-6-cycloalkyl and linear or branched C_1-8-alkyl which can be substituted with hydroxy, alkoxy, cycloalkyl, C_1-8-alkoxycarbonyl (RO-CO-), where R denotes unsubstituted alkyl, or R₃ and R₄, together with nitrogen atom with which they are bonded form optionally substituted 3-6-member ring which optionally can contain one or more additional heteroatoms selected from N and O, or its pharmaceutically acceptable salts. Also disclosed is use of complex compounds and pharmaceutical composition.;EFFECT: obtained compounds are intended for use as therapeutic agents for treating and/or preventing symptoms of iron deficiency and iron-deficiency anaemia.;16 cl, 1 tbl, 80 ex

机译：技术领域本发明涉及复合铁化合物（III）。化合物包含至少一种式（I）的配体：，其中箭头表示与一个或多个铁原子，R _{1 选自直链或支链的C _{1-8 -烷基，可以被C _{1-6取代-烷氧基（RO-），其中R表示未取代的烷基，或C _{1-8 -烷氧基羰基（RO-CO-），其中R表示未取代的烷基; R _{2 选自氢原子，未取代的C _{1-8 -烷基，卤素原子和氰基或R _{1 和R _{2 及其与之键合的碳原子形成未取代的5或6元环，R _{3 和R _{4 选自氢原子，吗啉基，C _{3-6 -环烷基和可被羟基，烷氧基，环烷基取代的直链或支链C _{1-8 -烷基，C _{1-8 -烷氧羰基（RO-CO-），其中R表示未取代的烷基，或R _{3 和R _{4 与它们键合的氮原子形成任选取代的3-6元环，该环可以任选地包含一个或多个选自N和O的其他杂原子或其药学上可接受的盐。还公开了复杂化合物和药物组合物的用途。效果：所得化合物旨在用作治疗剂和/或预防铁缺乏症和铁缺乏症贫血的症状的治疗剂。16 cl，1 tbl，80 ex}}}}}}}}}}}}}}}

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公开/公告号RU2589710C2

专利类型
公开/公告日2016-07-10

原文格式PDF
申请/专利权人 VIFOR (INTERNATSIONAL) AG;
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申请/专利号RU20120144844
发明设计人 BARK TOMAS (CH);BUR VILM (DE);BURKKHARDT SYUZANNA (CH);BURGERT MIKHAEL (DE);KANKLINI KAMILLO (CH);DYURRENBERGER FRANTS (CH);FUNK FELIKS (CH);GEJSSER PETER (CH);KALOGERAKIS ARIS (CH);MAJER SIMONA (CH);FILIPP ERIK (CH);RAJM SHTEFAN (CH);ZIBER DIANA (CH);SHMITT JORG (CH);SHVARTS KATRIN (CH);
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申请日2011-03-22
分类号C07F15/02;A61K31/295;A61K31/555;A61P7/06;
国家 RU
入库时间 2022-08-21 14:10:38

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