INSULIN-LIKE GROWTH FACTORS [Review]

Schmid C

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INSULIN-LIKE GROWTH FACTORS [Review]

机译：胰岛素样生长因子[综述]

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The insulin-like growth factors I and II are single chain polypeptides homologous to proinsulin. IGF I and IGF II contribute to cell regulation and stimulate protein synthesis via signaling through type I receptors which are homologous to insulin receptors and activate phosphorylation cascades. IGFs enhance the proliferation of chondocytes and the proliferation of their collagen and proteoglycan matrix; IGFs stimulate longitudinal (endochondral) bone growth. Throughout life, IGFs are constitutvely expressed ubiquitous factors which help to maintain the survival of differentiated cells, Increased expression is found during growth and tissue repair, Six specific binding proteins, IGFBP 1-6, allow additional tissue compartment specific control of IGF activity; IGFBP production favours storage and IGFBP cleavage leads to activation.

机译：胰岛素样生长因子I和II是与胰岛素原同源的单链多肽。 IGF I和IGF II通过与胰岛素受体同源的I型受体发出信号并激活磷酸化级联，从而促进细胞调节并刺激蛋白质合成。 IGFs增强软骨细胞的增殖及其胶原和蛋白聚糖基质的增殖; IGF刺激纵向（软骨内）骨骼生长。在整个生命过程中，IGF都是组成型表达的普遍存在的因子，有助于维持分化细胞的存活。在生长和组织修复过程中发现表达增加。六种特异性结合蛋白IGFBP 1-6可以对IGF活性进行额外的组织区室特异性控制; IGFBP的产生有利于储存，而IGFBP的切割会导致活化。

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《Cell biology international.》 |1995年第5期|共13页
作者
Schmid C;
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正文语种 eng
中图分类细胞生物学;
关键词
Multiplication stimulating activity; Messenger ribonucleic acid; Factor ii gene; Igf i; Binding protein; Transgenic mice; Rat liver; Oligodendrocyte development; Hypophysectomized rats; Tissue; concentrations;

机译：增殖刺激活性;Messenger核糖核酸;因子ii基因;Igf i;结合蛋白;转基因小鼠;大鼠肝脏;少突胶质细胞发育;经组织切除的大鼠;组织;浓度;

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1. Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 receptor gene expression is a useful predictor of liver metastasis from colorectal cancer. [J] . Oshima T, Akaike M, Yoshihara K, Oncology reports . 2008,第2期

机译：大肠癌患者基质金属蛋白酶7，胰岛素样生长因子-1，胰岛素样生长因子-2和胰岛素样生长因子-1受体基因表达的临床病理意义：胰岛素样生长因子-1受体基因表达是大肠癌肝转移的有用预测指标。
2. Stability of frozen serum levels of insulin-like growth factor-I, insulin-like growth factor-II, insulin-like growth factor binding protein-3, transforming growth factor beta, soluble Fas, and superoxide dismutase activity for the JACC study. [J] . Ito Y, Nakachi K, Imai K, Journal of epidemiology / . 2005,第Suppla1期

机译：JACC研究中，胰岛素样生长因子-I，胰岛素样生长因子-II，胰岛素样生长因子结合蛋白-3，转化生长因子β，可溶性Fas和超氧化物歧化酶活性的冷冻血清水平的稳定性。
3. Stability of frozen serum levels of insulin-like growth factor-I, insulin-like growth factor-II, insulin-like growth factor binding protein-3, transforming growth factor beta, soluble Fas, and superoxide dismutase activity for the JACC study. [J] . Ito Y, Nakachi K, Imai K, Journal of epidemiology / . 2005,第Suppla1期

机译：JACC研究中，胰岛素样生长因子-I，胰岛素样生长因子-II，胰岛素样生长因子结合蛋白-3，转化生长因子β，可溶性Fas和超氧化物歧化酶活性的冷冻血清水平的稳定性。
4. EFFECT OF NUTRITIONAL STATUS ON PLASMA CONCENTRATIONS OF INSULINLIKE GROWTH FACTOR BINDING PROTEIN-3 AND INSULIN-LIKE GROWTH FACTOR-I IN PASTURE-FED HOLSTEIN-FRIESIAN COWS [C] . F.Y. OBESE, K.L. MACMILLAN, S. HUMPHRYS, Biennial Conference of the Australia Society of Animal Production . 2004

机译：营养状况对浆液蛋白3和胰岛素样生长因子-1在牧场喂养荷斯坦 - 弗里斯奶牛的血浆浓度对血浆浓度的影响
5. Evaluation of serum insulin-like growth factor binding proteins and the insulin-like growth factor binding protein-2 locus for potential associations with growth, carcass merit and meat quality in beef cattle. [D] . Pagan, Melvin. 2002

机译：评价血清胰岛素样生长因子结合蛋白和胰岛素样生长因子结合蛋白2位点与肉牛生长，屠体价值和肉质的潜在关联。
6. Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growth factor-1 resulting in elevated sustainable insulin-like growth factor-1 and insulin-like growth factor binding protein 3 plasma levels: a case report [O] . Eric R Braverman, Abdalla Bowirrat, Uma J Damle, 2010

机译：结合生长激素和胰岛素样生长因子-1的成人生长激素缺乏症治疗导致持续的胰岛素样生长因子-1和胰岛素样生长因子结合蛋白3血浆水平升高：一例
7. Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: Insulin-like growth factor-1 receptor gene expression is a useful predictor of liver metastasis from colorectal cancer [O] . Takashi Oshima 1994

机译：基质金属蛋白酶-7，胰岛素样生长因子-1，胰岛素样生长因子-2和胰岛素样生长因子-1受体在结肠直肠癌患者中的临床病理学意义：胰岛素样生长因子-1受体基因表达是来自结肠直肠癌的肝转移的有用预测因子
8. Insulin-Like Growth Factor Binding Protein-1 Interacts with Integrins to Inhibit Insulin-Like Growth Factor-Induced Breast Cancer Growth and Migration [R] . Gross, J. M. 2003

机译：胰岛素样生长因子结合蛋白-1与整合素相互作用，抑制胰岛素样生长因子诱导的乳腺癌生长和迁移

INSULIN-LIKE GROWTH FACTORS [Review]

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