Pregnancy and lactation

D.J. Steyn; G.M. Anderson; D. R. Grattan

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Pregnancy and lactation

机译：怀孕和哺乳

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Under normal conditions prolactin stimulates arcuate dopaminergic neurons, which in turn inhibit piolactin release. Prior to parturition these dopaminergic neurons become unresponsive to prolactin, resulting in reduced dopamine release and the consequent antepartum piolactin surge Previous data from our lab has implicated suppressors of cytokine signalling (SOCS) proteins in mediating this change of response to prolactin, as during the antepartum prolactin surge we saw a marked induction in SOCS mRNA.

机译：在正常情况下，催乳素会刺激弓形的多巴胺能神经元，进而抑制螺信息素的释放。在分娩前，这些多巴胺能神经元对催乳素无反应，导致多巴胺释放减少，随之而来的产前泌乳素激增。来自我们实验室的先前数据暗示了细胞因子信号转导（SOCS）抑制因子在介导对催乳素的这种反应变化，如产前催乳素激增，我们看到了SOCS mRNA的明显诱导。

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《Frontiers in neuroendocrinology》 |2006年第1期|共3页
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D.J. Steyn; G.M. Anderson; D. R. Grattan;
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中图分类神经病学与精神病学;
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Pregnancy and lactation

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