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Cognition and memory

机译:认知与记忆

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摘要

Activity-regulated cytoskeletal protein (Arc) is an.effector immediate early gene involved in consolidation of long-term memory, Since activation of glucocorticoid receptors is prerequisite for memory consolidation, we therefore aimed to study the effect of acute restraint stress on Arc gene expression in adrenalectomized rats. Restraint stress produced a significant and immediate increase in Arc gene expression in the medial prefr ontal cortex, but not in the parietal cortex or in the pyramidal cell layer of the hippocampus. This was surprising because novelty has been shown to produce an increase in the hippocampus,. We speculated if the regulation of Arc gene expression was dependent on the nature of the stressor and modulated by circulating glucocor ticoids. The basal level of Arc mRNA in adrenalectomized animals was high in the prefrontal cortex and no change was achieved after stress in these animals.
机译:活性调节的细胞骨架蛋白(Arc)是参与长期记忆巩固的有效早期基因。由于糖皮质激素受体的激活是记忆巩固的先决条件,因此我们旨在研究急性约束应激对Arc基因表达的影响。在肾上腺切除的大鼠中。约束压力使内侧前皮层的Arc基因表达显着增加,但立即增加,而顶叶皮层或海马锥体细胞层却没有。这是令人惊讶的,因为已经表明新颖性会引起海马体的增加。我们推测Arc基因表达的调节是否取决于应激源的性质并受循环糖皮质激素的调节。在肾上腺切除术动物的额叶前额叶皮质中,Arc mRNA的基础水平很高,并且在这些动物承受压力后没有变化。

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