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首页> 外文期刊>Frontiers in neuroendocrinology >Psychoneuroendocrinology
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Psychoneuroendocrinology

机译：心理神经内分泌学

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Rationale: Several studies suggest that women have more difficulty than men with smoking cessation. Many smoking withdrawal symptoms are also symptoms of depression, a disorder with an increased incidence and prevalence in women. In depression, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is common with high baseline cortisol levels and diminished glucocor-ticoid negative feedback often reported Studies have also reported a negative relationship between depressive symptoms and plasma levels of dehydroepiandrosterone (DHEA) or its sulfated metabolite, DHEAS Recent studies suggest, however, that the ratio between DHEA(S) and cortisol may better predict mood and cognition than levels of either steroid alone. We thus hypothesized that smoking cessation-induced changes in the plasma DHEA(S) to cortisol ratio would correlate with changes in depressive symptoms and predict relapse in a gender-specific manner.
机译：基本原理：多项研究表明，戒烟女性比男性更有困难。许多戒烟症状也是抑郁症的症状，这是一种女性发病率和患病率增加的疾病。在抑郁症中，下丘脑-垂体-肾上腺（HPA）轴失调常见于基线皮质醇水平高且糖皮质激素负反馈减少的现象，经常有研究报道。然而，最近的研究表明，DHEA（S）和皮质醇之间的比率比单独使用任何一种类固醇的水平都能更好地预测情绪和认知。因此，我们假设吸烟中止引起的血浆DHEA（S）与皮质醇比率的变化将与抑郁症状的变化相关，并以性别特异性方式预测复发。

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