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首页> 外文期刊>Frontiers in neuroendocrinology >The neuroendocrine basis of social recognition.
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The neuroendocrine basis of social recognition.

机译：社会认可的神经内分泌基础。

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All social relationships are dependent on an organism's ability to remember conspecifics. Social memory may be a unique form of memory, critical for reproduction, territorial defense, and the establishment of dominance hierarchies in a natural context. In the laboratory, social memory can be assessed reliably by measuring the reduction in investigation of a familiar partner relative to novel conspecifics. The neurohypophyseal neuropeptides oxytocin and vasopressin have been shown to influence a number of forms of social behavior, including affiliation, aggression, and reproduction. This article reviews vasopressin and oxytocin effects on social cognition, particularly the acquisition and retention of social recognition in rats and mice. Studies in rats have demonstrated that vasopressin in specific neural pathways, such as the lateral septum, is necessary for social recognition. As vasopressin facilitates recall when given after an initial encounter, the peptide appears important for the consolidation not the acquisition of a social memory. Although oxytocin has complex effects on social memory in rats, mice with a null mutation of the oxytocin gene are completely socially amnestic without other cognitive deficits evident. As oxytocin given centrally before but not after the initial encounter restores social recognition in these mutant mice, the neuropeptide appears critical for the acquisition rather than the consolidation phase of memory. Oxytocin's effects on social memory are mediated via a discrete cell population in the medial amygdala. These findings support the hypothesis that vasopressin and oxytocin are essential for social memory, although they appear to influence different cognitive processes and may modulate different neural systems. (c) Elsevier Science.
机译：所有的社会关系都取决于生物体记住特定物种的能力。社会记忆可能是一种独特的记忆形式，对于自然环境中的繁殖，领土防御和建立统治等级至关重要。在实验室中，可以通过测量熟悉的伴侣相对于新物种的调查减少来可靠地评估社交记忆。神经下垂体神经肽催产素和加压素已显示出影响多种社会行为形式，包括从属，侵略和生殖。本文综述了加压素和催产素对社交认知的影响，尤其是大鼠和小鼠社交认知的获得和保留。在大鼠中的研究表明，特定的神经通路（例如外侧隔）中的加压素对于获得社会认可是必要的。由于初次接触后给予加压素有助于回忆，因此该肽对于巩固固本而不是获得社交记忆很重要。尽管催产素对大鼠的社交记忆具有复杂的作用，但催产素基因无效突变的小鼠完全社交失忆，没有其他明显的认知缺陷。在这些突变小鼠中，在初次接触之前而不是之后集中给予催产素可以恢复社会认可度，因此神经肽似乎对于获得至关重要，而不是记忆的巩固阶段。催产素对社会记忆的影响是通过杏仁核内侧的离散细胞群介导的。这些发现支持了血管加压素和催产素对于社会记忆必不可少的假设，尽管它们似乎影响不同的认知过程并可能调节不同的神经系统。 （c）爱思唯尔科学。

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