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首页> 外文期刊>Frontiers in neuroendocrinology >Thyroid hormones and the brain.
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Thyroid hormones and the brain.

机译:甲状腺激素和大脑。

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摘要

Significant progress has been made over the past 2 decades toward understanding the molecular basis of thyroid hormone action. It is now widely accepted that thyroid hormones play predominantly a nuclear role and function by regulating the transcription of specific target genes. Understanding thyroid hormone action at the tissue and organismic level requires assessment of the thyroid hormone response apparatus and identification of specific target genes. Progress toward uncovering the molecular basis of thyroid hormone action during mammalian brain development is advancing rapidly. This commentary provides a brief overview of the molecular basis of thyroid hormone action followed by three sections detailing thyroid hormone regulation of brain development at the functional, cellular, and molecular levels. Each section is followed by a discussion of unresolved issues and an analysis of our current level of understanding of each topic.
机译:在过去的20年中,在了解甲状腺激素作用的分子基础方面取得了重大进展。现在,人们普遍认为甲状腺激素通过调节特定靶基因的转录而起主要的核作用和功能。了解甲状腺激素在组织和机体水平的作用需要评估甲状腺激素反应仪并鉴定特定的靶基因。在揭示哺乳动物大脑发育过程中甲状腺激素作用的分子基础方面,进展迅速。该评论简要概述了甲状腺激素作用的分子基础,其后三部分详细介绍了甲状腺激素在功能,细胞和分子水平上对大脑发育的调节。每个部分后面都讨论了未解决的问题,并分析了我们对每个主题的当前理解水平。

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