...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in neuroendocrinology >Hypothalamic hormones and cancer.
【24h】

Hypothalamic hormones and cancer.

机译：下丘脑激素和癌症。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The use of peptide analogs for the therapy of various cancers is reviewed. Inhibition of the pituitary-gonadal axis forms the basis for oncological applications of luteinizing hormone-releasing hormone (LH-RH) agonists and antagonists, but direct effects on tumors may also play a role. Analogs of somatostatin are likewise used for treatment of various tumors. Radiolabeled somatostatin analogs have been successfully applied for the localization of tumors expressing somatostatin receptors. Studies on the role of tumoral LH-RH, growth hormone-releasing hormone (GH-RH), and bombesin/GRP and their receptors in the proliferation of various tumors are summarized, but the complete elucidation of all the mechanisms involved will require much additional work. Human tumors producing hypothalamic hormones are also discussed. Treatment of many cancers remains a major challenge, but new therapeutic modalities are being developed based on antagonists of GH-RH and bombesin, which inhibit growth factors or their receptors. Other approaches consist of the use of cytotoxic analogs of LH-RH, bombesin, and somatostatin, which can be targeted to receptors for these peptides in various cancers and their metastases. These new classes of peptide analogs should lead to a more effective treatment for various cancers.
机译：综述了肽类似物在治疗各种癌症中的用途。垂体-性腺轴的抑制形成了黄体生成激素释放激素（LH-RH）激动剂和拮抗剂的肿瘤学基础，但对肿瘤的直接作用也可能起作用。生长抑素的类似物同样用于治疗各种肿瘤。放射性标记的生长抑素类似物已成功地用于表达生长抑素受体的肿瘤的定位。总结了对肿瘤LH-R​​H，生长激素释放激素（GH-RH）和BomSin / GRP及其受体在各种肿瘤增殖中的作用的研究，但要完全阐明所有涉及的机制，还需要付出更多的努力。工作。还讨论了产生下丘脑激素的人类肿瘤。许多癌症的治疗仍然是一个主要挑战，但是基于GH-RH和蛙皮素的拮抗剂正在开发新的治疗方法，它们可以抑制生长因子或其受体。其他方法包括使用LH-RH，蛙皮素和生长抑素的细胞毒性类似物，它们可以靶向这些肽在各种癌症及其转移中的受体。这些新的肽类似物类别应导致对各种癌症的更有效治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号