...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in neuroendocrinology >Stress and the aging hippocampus.
【24h】

Stress and the aging hippocampus.

机译：压力和海马老化。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The "glucocorticoid cascade hypothesis" of hippocampal aging has stimulated a great deal of research into the neuroendocrine aspects of aging and the role of glucocorticoids, in particular. Besides strengthening the methods for investigating the aging brain, this research has revealed that the interactions between glucocorticoids and hippocampal neurons are far more complicated than originally envisioned and involve the participation of neurotransmitter systems, particularly the excitatory amino acids, as well as calcium ions and neurotrophins. New information has provided insights into the role of early experience in determining individual differences in brain and body aging by setting the reactivity of the hypothalamopituitary-adrenal axis and the autonomic nervous system. As a result of this research and advances in neuroscience and the study of aging, we now have a far more sophisticated view of the interactions among genes, early development, and environmental influences, as well as a greater appreciation of events at the cellular and molecular levels which protect neurons, and a greater appreciation of pathways of neuronal damage and destruction. While documenting the ultimate vulnerability of the brain to stressful challenges and to the aging process, the net result of this research has highlighted the resilience of the brain and offered new hope for treatment strategies for promoting the health of the aging brain. Copyright 1999 Academic Press.
机译：海马衰老的“糖皮质激素级联假说”激发了关于衰老的神经内分泌方面特别是糖皮质激素作用的大量研究。除了加强研究衰老大脑的方法外，这项研究还表明，糖皮质激素与海马神经元之间的相互作用比最初设想的要复杂得多，并且涉及神经递质系统的参与，尤其是兴奋性氨基酸以及钙离子和神经营养蛋白的参与。 。新的信息通过设置下丘脑垂体-肾上腺轴和自主神经系统的反应性，提供了对早期经验在确定大脑和身体衰老个体差异中的作用的见解。由于这项研究以及神经科学和衰老研究的进展，我们现在对基因之间的相互作用，早期发育和环境影响以及对细胞和分子事件的认识有了更深入的了解。保护神经元的水平，以及对神经元损伤和破坏途径的更多了解。在记录大脑对压力挑战和衰老过程的最终脆弱性的同时，这项研究的最终结果突出了大脑的弹性，并为促进衰老的大脑健康的治疗策略提供了新的希望。版权所有1999 Academic Press。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号