Spotlighting adult stem cells: advances, pitfalls, and challenges

Altshuler Anna; Wickstroem Sara A.; Shalom-Feuerstein Ruby

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Spotlighting adult stem cells: advances, pitfalls, and challenges

机译：Spotlighting adult stem cells: advances, pitfalls, and challenges

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摘要

The existence of stem cells (SCs) at the tip of the cellular differentiation hierarchy has fascinated the scientific community ever since their discovery in the early 1950s to 1960s. Despite the remarkable success of the SC theory and the development of SC-based treatments, fundamental features of SCs remain enigmatic. Recent advances in single-cell lineage tracing, live imaging, and genomic technologies have allowed capture of life histories and transcriptional signatures of individual cells, leaving SCs much less space to 'hide'. Focusing on epithelial SCs and comparing them to other SCs, we discuss new paradigms of the SC niche, dynamics, and pathology, highlighting key open questions in SC biology that need to be resolved for harnessing SC potential in regenerative medicine.

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来源
《Trends in Cell Biology》 |2023年第6期|477-494|共18页
作者
Altshuler Anna; Wickstroem Sara A.; Shalom-Feuerstein Ruby;
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作者单位

Technion Israel Inst Technol;

Max Planck Inst Mol Biomed;

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原文格式 PDF
正文语种英语
中图分类 Q28;
关键词
LABEL-RETAINING CELLS; MOUSE BONE MARROW; HAIR FOLLICLE; DNA-DAMAGE; SMALL-INTESTINE; COMPETITIVE INTERACTIONS; RADIATION SENSITIVITY; HUMAN EPIDERMIS; WOUND REPAIR; FATE;

Spotlighting adult stem cells: advances, pitfalls, and challenges

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