Targeting of biomolecular condensates to the autophagy pathway

Ma Xinyu; Li Pilong; Ge Liang

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Targeting of biomolecular condensates to the autophagy pathway

机译：Targeting of biomolecular condensates to the autophagy pathway

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Biomolecular condensates are membraneless compartments formed by liquid- liquid phase separation. They can phase transit into gel-like and solid states. The amount and state of biomolecular condensates must be tightly regulated to main-tain normal cellular function. Autophagy targets biomolecular condensates to the lysosome for degradation or other purposes, which we term biocondensophagy. In biocondensophagy, autophagy receptors recognize biomolecular condensates and target them to the autophagosome, the vesicle carrier of autophagy. Multiple types of autophagy receptors have been identified and they are specifically involved in targeting biomolecular condensates with different phase transition states. The receptors also organize the phase transition of biomolecular conden-sate to facilitate biocondensophagy. Here, we briefly discuss the latest discoveries regarding how biomolecular condensates are recognized by autophagy receptors.

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来源
《Trends in Cell Biology》 |2023年第6期|505-516|共12页
作者
Ma Xinyu; Li Pilong; Ge Liang;
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作者单位

State Key Lab Membrane Biol;

Tsinghua Peking Ctr Life Sci;

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原文格式 PDF
正文语种英语
中图分类 Q28;
关键词
MEDIATED SELECTIVE AUTOPHAGY; LIQUID PHASE-SEPARATION; ENDOPLASMIC-RETICULUM; AMINOPEPTIDASE-I; LYSOSOME FUSION; PROTEIN; DEGRADATION; MEMBRANE; CYTOPLASM; RECEPTOR;

Targeting of biomolecular condensates to the autophagy pathway

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