...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >Formulation and statistical optimization of multiple-unit ibuprofen-loaded buoyant system using 2~3-factorial design
【24h】

Formulation and statistical optimization of multiple-unit ibuprofen-loaded buoyant system using 2~3-factorial design

机译：制定和统计优化多菱形ibuprofen-loaded活跃的系统使用2 ~ 3的阶乘设计

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This present investigation deals with the development and optimization of buoyant beads containing ibuprofen by emulsion-gelation method for gastroretentive delivery. The effect of three independent process variables like amount of sodium alginate, magnesium stearate, and liquid paraffin on drug entrapment, density, and drug release of buoyant beads containing ibuprofen was optimized using 2~3 factorial design. The observed responses were coincided well with the predicted values, given by the optimization technique. The optimized beads showed drug entrapment efficiency of 83.07 ±3.25%, density of 0.89 ±0.11 g/cm~3 cumulative drug release of 35.02 ± 1.24% after 8 h, and floated well over 8 h in simulated gastric fluid (pH 1.2) with 4,50 min buoyant lag-time. The average size of all buoyant beads ranged from 1.43 ± 0.05 to 1.82 ± 0.14 mm. The buoyant beads were characterized by SEM and FTIR spectroscopy for surface morphology and excipients-drug interaction analysis, respectively. All these beads showed prolonged sustained release of ibuprofen over 8h in simulated gastric fluid (pH 1.2). The ibuprofen release profile from these buoyant beads followed Korsmeyer-Peppas model over a period of 8h with anomalous (non-Fickian) diffusion mechanism for drug release.
机译：现在调查处理开发和优化的珠子emulsion-gelation含布洛芬的方法gastroretentive交付。独立的流程变量的海藻酸钠、硬脂酸镁和液体石蜡药物滞留、密度和药物释放含布洛芬的活跃的珠子使用2 ~ 3的阶乘设计进行了优化。观察到的反应是同时的预计值,给出的优化技术。截留效率为83.07±3.25%,密度0.89±0.11克/厘米~ 3累积释放药物8 h后35.02±1.24%,浮动超过8h在模拟胃液体(pH值1.2)4、50岁最小的滞后时间。活跃的珠子范围从1.43±0.05,1.82±0.14毫米。表面形态的扫描电镜和红外光谱和excipients-drug交互分析,分别。持续释放的布洛芬/ 8 h模拟胃液体(pH值1.2)。发布概要文件从这些活跃的珠子在一段8 h Korsmeyer-Peppas模型异常(non-Fickian)扩散机制药物释放。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号