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首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >In-situ monitoring of pharmaceutical and specialty chemicals crystallization processes using endoscopy-stroboscopy and multivariate image analysis
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In-situ monitoring of pharmaceutical and specialty chemicals crystallization processes using endoscopy-stroboscopy and multivariate image analysis

机译：现场监测药品和专业化学物质结晶过程使用endoscopy-stroboscopy和多元图像分析

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摘要

This contribution presents the proof of concept of endoscopy-stroboscopy based in situ low-cost imaging of crystallization processes. This low-cost sensor currently is widely spread in the field of medical diagnosis of human vocal chords and this work presents its application in the context of pharmaceutical and chemical crystallization process monitoring. The model compounds used in this study are the active pharmaceutical ingredient (API) flufenamic acid and citric acid. Since the acquired images are colored, the second aim of the paper is to evaluate the principal component (PCA) based multivariate image analysis (MIA) as a color to gray scale transformation method, and to compare it to the National Television System Committee (NTSC) standard, which uses fixed weights. It was found that particle color, transparency, size and shape related information based on visual inspection is feasible using the endoscope-stroboscope system. The MIA results show that in the case of transparent particles the red, green, blue channels contribute equally to the total information content of color images. The acquisition price of the ATMOS endoscope is similar to that of a laboratory turbidity probe, feature which is relevant for the widespread use of this sensor.
机译：这贡献礼物的概念证明endoscopy-stroboscopy原位低成本为基础结晶过程的成像。低成本传感器目前被广泛传播人类的声带的医学诊断领域这提供了应用程序的工作制药和化学结晶过程监控。化合物在这项研究中的应用是活跃的药物成分(API)氟芬那酸和柠檬酸。彩色的,论文的第二个目的是评估基于主成分(PCA)多元图像分析(MIA)作为一个颜色灰度变换方法,并比较美国国家电视系统委员会(NTSC)标准,使用固定的权重。发现粒子的颜色,透明度,大小和基于视觉的形状相关信息使用的检测是可行的endoscope-stroboscope系统。显示在透明粒子红、绿、蓝通道同样的贡献彩色图像的总信息内容。大气压内窥镜的收购价格类似于实验室的浊度调查,与广泛使用相关的特性这个传感器。

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