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首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >Characterization of hydrodynamics in membrane chromatography devices using magnetic resonance imaging and computational fluid dynamics
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Characterization of hydrodynamics in membrane chromatography devices using magnetic resonance imaging and computational fluid dynamics

机译：表征膜的流体动力学色谱设备用核磁共振成像和计算流体动力学

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Membrane chromatography (MC) is increasingly used in downstream processes for biomolecule purification as a large range of axial or radial flow commercial membranes is available. The design of these devices plays a major role on flow distribution and biomolecule binding. To better understand the hydrodynamic in MC devices, the velocity field was measured for the first time using magnetic resonance imaging (MRI) and calculated by computational fluid dynamics (CFD) on reconstructed geometries obtained by MRI. The CFD model solved Navier-Stokes and Brinkman equations in the free and membrane regions, respectively. Both axial flow and radial flow devices were investigated. For the axial flow device, the velocities were found higher at the periphery for all membrane bed heights. This result suggests that the whole membrane housing has an effect on flow distribution, the inlet and outlet distributors as well as the peripheral walls of the module. In the radial flow device, a high decrease in velocity was observed along the membrane bed height, which could be due to the reduction of the diameter section at the module outlet. Overall, it was concluded that MRI and CFD are powerful methods to better understand the hydrodynamics within MC devices. (C) 2016 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
机译：膜色谱法(MC)正越来越多地使用在下游的生物分子的过程作为一个大范围的轴向或径向净化流商业膜是可用的。这些设备的设计中起着重要作用流分布和生物分子绑定。更好地理解MC的水动力设备,第一个的速度场进行了测量使用磁共振成像(MRI)和时间计算了计算流体动力学(CFD)在重建的几何图形通过核磁共振。CFD模型解决了n - s和边缘主义者方程在自由和膜区域,分别。设备进行调查。设备,速度被发现在高外围所有膜床高度。结果表明,整个膜住房会影响流量分布、进口和出口经销商以及外围墙的模块。高速度是下降沿膜床层高度,这可能是由于减少直径部分的模块出口。CFD是强大的方法来更好地理解流体力学在MC设备。化学工程师学会。爱思唯尔帐面价值保留所有权利。

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