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首页> 外文期刊>Hormone molecular biology and clinical investigation. >Characterizing the differential physiological effects of adipocytokines visfatin and resistin in liver cancer cells
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Characterizing the differential physiological effects of adipocytokines visfatin and resistin in liver cancer cells

机译：描述微分生理影响adipocytokines visfatin和抵抗素在肝癌细胞

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摘要

Liver cancer is the sixth most common cancer and the leading cause of cancer deaths worldwide [1]. In the US, the American Cancer Society estimated that approximately 40,710 new cases of liver cancer were diagnosed in 2017 [1]. Also, approximately 28,290 of these newly diagnosed patients will die due to liver cancer [1]. Since 1980, liver cancer incidence has more than tripled and deaths have increased by almost 3% per year since 2000 [1]. The rise in liver cancer incidence coincides with the current obesity trend with 1/3 of adults being obese [2], [3]. The link between obesity and liver cancer is likely to be mediated by a state of chronic inflammation [3]. Obesity along with low grade inflammation results in elevated plasma concentrations of insulin and insulin-like growth factor 1 (IGF-1), increased secretion of adipokines such as visfatin and resistin along with inflammatory cells including macrophages [3]. The adipokines, visfatin and resistin, may facilitate cancer cells ability to proliferate, invade, migrate and metastasize. Due to the current obesity epidemic, there is clinical relevance for understanding the mechanisms by which obesity modulates liver cancer.
机译：肝癌是第六个最常见的癌症全世界癌症死亡的主要原因[1]。在美国,美国癌症协会估计大约40710新病例的肝脏在2017年被诊断出癌症[1]。大约28290名新诊断的由于肝癌病人会死亡[1]。1980年,肝癌的发病率已经超过三倍和死亡人数增加了近3%自2000年以来每年[1]。伴随着当前肥胖发生率趋势与1/3的成年人肥胖[2],[3]。肥胖和肝癌之间的联系可能是由一种慢性的状态炎症[3]。炎症导致升高的血浆浓度的胰岛素和胰岛素样生长因子1 (igf - 1)的分泌增加发病visfatin和抵抗素等与炎症细胞包括巨噬细胞[3]。促进肿瘤细胞增殖的能力,入侵、迁移和转移。当前肥胖流行病,临床对理解机制的相关性而肥胖调节肝癌。

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