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首页> 外文期刊>Hormone molecular biology and clinical investigation. >Impact of progestogens on hemostasis
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Impact of progestogens on hemostasis

机译：孕激素影响止血

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Venous thromboembolism (VTE) is a specific health risk for women. Pregnancy increases the risk of VTE approximately four-fold, whereas an additional five-fold increased risk is observed in the puerperium [1]. A large number of women worldwide are exposed to increased risk of VTE due to the use of combined hormonal contraceptives (COCs) or hormone therapy (HT) after the menopause. Even women undergoing infertility treatment may be exposed to situations of significantly increased risk of VTE [2]. Several studies have established a two-to four-fold increased risk of VTE for users of HT compared with non-users [3] which is comparable to the attributable risk of COCs. The risk for VTE induced by HT is, however, higher in absolute figures because of the age factor per se, but also dependent on the composition of the HT used, as users of estrogen-only preparations have lower risk of VTE than women receiving COCs [4]. Also, the dose and the route of administration seem of importance, as women treated with transdermal HT have lower risk of VTE than women receiving orally administered HT as has been consistently demonstrated in clinical studies [5]. Moreover, epidemiological and pharmacological factors may contribute to the precipitation of VTE among exogenous sex-steroid users.
机译：静脉血栓栓塞(VTE)是一个特定的健康女性的风险。静脉血栓栓塞约4倍,而一个额外的风险增加五倍在产褥期[1]。全球面临增加静脉血栓栓塞的风险由于联合激素的使用避孕药(COCs)或激素治疗(HT)在更年期之后。不孕不育治疗可能会接触到的情况下显著增加静脉血栓栓塞的风险[2]。4倍增加HT用户的静脉血栓栓塞的风险类似的增长量比[3]由于COCs的风险。然而,HT引起的静脉血栓栓塞是绝对高数据本身由于年龄因素,但也依赖于HT的构成,雌激素制剂具有较低的用户静脉血栓栓塞的风险比女性接受COCs[4]。的剂量和给药途径似乎重要性,是女性的皮肤HT对待降低静脉血栓栓塞的风险比女性收到了吗口头管理HT一直在临床研究[5]。流行病学和药理因素可能导致静脉血栓栓塞的降水外生的性腺用户。

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