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首页> 外文期刊>Trends in Cell Biology >Ror receptor tyrosine kinases: orphans no more
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Ror receptor tyrosine kinases: orphans no more

机译：Ror受体酪氨酸激酶：不再是孤儿

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摘要

Receptor tyrosine kinase-like orphan receptor (Ror) proteins are a conserved family of tyrosine kinase receptors that function in developmental processes including skeletal and neuronal development, cell movement and cell polarity. Although Ror proteins were originally named because the associated ligand and signaling pathway were unknown, recent studies in multiple species have now established that Ror proteins are Wnt receptors. Depending on the cellular context, Ror proteins can either activate or repress transcription of Wnt target genes and can modulate Wnt signaling by sequestering Wnt ligands. New evidence implicates Ror proteins in planar cell polarity, an alternative Wnt pathway. Here, we review the progress made in understanding these mysterious proteins and, in particular, we focus on their function as Wnt receptors.
机译：受体酪氨酸激酶样孤儿受体（Ror）蛋白是酪氨酸激酶受体的保守家族，其在包括骨骼和神经元发育，细胞运动和细胞极性在内的发育过程中起作用。尽管Ror蛋白最初的命名是因为未知的相关配体和信号传导途径，但最近在多个物种中的研究已经确定Ror蛋白是Wnt受体。根据细胞情况，Ror蛋白可以激活或抑制Wnt靶基因的转录，并可以通过隔离Wnt配体来调节Wnt信号传导。新的证据表明Ror蛋白在平面细胞极性中是另一种Wnt途径。在这里，我们回顾了在理解这些神秘蛋白质方面取得的进展，特别是，我们专注于它们作为Wnt受体的功能。

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