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首页> 外文期刊>Nuclear Instruments & Methods in Physics Research. B, Beam Interactions with Materials and Atoms >Fibroblasts adhesion on ion beam modified polyethylene
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Fibroblasts adhesion on ion beam modified polyethylene

机译：成纤维细胞在离子束改性聚乙烯上的附着力

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摘要

Polyethylene (PE) was irradiated with 15 keV O~+, P~+ and Ar~+ ions to the fluences from 3 x 10~(12) to 1 x 10~(15) cm~(-2). The changes of surface structure and polarity and oxygen concentration were examined on pristine and as-irradiated PE. The in vitro adhesion of rat 3T3 fibroblasts on the modified PE was evaluated 24 h after inoculation. Degradation of PE is manifested by the creation of conjugated double bonds and oxidation of the PE main chain. It was proved that the implanted P atoms are chemically bound onto degraded polymer chain. Wettability of the polymer surface is affected by the structure and composition of the modified surface layer. In comparison with pristine PE (ⅰ) higher cell adhesion is observed on implanted PE and (?) the cells cultivated on implanted PE are larger and their adherence is significantly more homogeneous. The enhancement of 3T3 cells adhesion is highest and smallest for PE implanted with O~+ and Ar~+ ions, respectively. Highest cell adhesion was observed on PE implanted to the fluence of 1 x 10~(13) cm~(-2) regardless of the ion specie. It was shown that the cell adhesion is related to the wettability of the PE surface and that there exists an optimal wettability with respect to the cell adhesion.
机译：用15 keV O〜+，P〜+和Ar〜+离子辐照聚乙烯（PE），使离子通量从3 x 10〜（12）到1 x 10〜（15）cm〜（-2）。在原始和辐照的PE上检查了表面结构和极性以及氧浓度的变化。接种后24小时评估大鼠3T3成纤维细胞在改性PE上的体外粘附。 PE的降解表现为共轭双键的产生和PE主链的氧化。事实证明，注入的P原子化学键合到降解的聚合物链上。聚合物表面的润湿性受改性表面层的结构和组成的影响。与原始PE相比，在植入的PE上观察到更高的细胞粘附性，而在植入的PE上培养的细胞更大，并且其粘附性更加均匀。对于植入O〜+和Ar〜+离子的PE，3T3细胞粘附的增强最高和最小。不论离子种类如何，在植入能量密度为1 x 10〜（13）cm〜（-2）的PE上观察到最高的细胞粘附性。结果表明，细胞粘附性与PE表面的润湿性有关，并且相对于细胞粘附性存在最佳的润湿性。

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