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首页> 外文期刊>Experimental Animals >Experimental Clostridium difficile infection in three germfree strains mice (C3H/He, C3H/He-scid, IQI)
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Experimental Clostridium difficile infection in three germfree strains mice (C3H/He, C3H/He-scid, IQI)

机译：三只无菌菌株小鼠（C3H / He，C3H / He-scid，IQI）的艰难梭菌感染实验

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Soft feces were observed in C3H/He-scid mouse in our SPF animal facility. An ampicillin-sensitive Clostridium difficile was isolated from the affected mice. In this study, differences in susceptibility to C. difficile were evaluated in three germfree mouse strains (C3H/Ue-scid, C3H/He and IQI). The mice were orally inoculated with the isolated C. diffecile and then the intestines of these mice were microbiologically and pathologically examined. The most remarkable histopathological changes were seen in the intestine of C3H/He-scid mice. Severe infiltration of inflammatory cells were observed in the mucosa of the cecum and the colon. Slight degree of the same changes were observed in the cecum of IQI mice. No histopathological changes were observed in those of C3H/He mice. It seems that an immune system plays an important role of enteritis in C. difficile-infection.
机译：在我们的SPF动物设施中的C3H / He-scid小鼠中观察到柔软的粪便。从受影响的小鼠中分离出对氨苄青霉素敏感的艰难梭菌。在这项研究中，在三种无菌小鼠品系（C3H / Ue-scid，C3H / He和IQI）中评估了对艰难梭菌的敏感性差异。用分离的艰难梭菌口服接种小鼠，然后通过微生物学和病理学检查这些小鼠的肠。在C3H / He-scid小鼠的肠道中观察到最明显的组织病理学变化。在盲肠和结肠的粘膜中观察到炎性细胞的严重浸润。在IQI小鼠的盲肠中观察到相同程度的轻微变化。在C3H / He小鼠中未观察到组织病理学变化。似乎免疫系统在艰难梭菌感染中起肠炎的重要作用。

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