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Effects of Lavender on Anxiety, Depression, and Physiological Parameters: Systematic Review and Meta-Analysis

机译:薰衣草对焦虑,抑郁和生理参数的影响:系统评价与荟萃分析

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PurposeThe recent evidence suggested substantial anxiolytic efficacy of lavender. The aim of this study was to examine the efficacy of lavender for anxiety, depression, and physiological parameters and to elucidate the differential effects of lavender on anxiety and depression by study characteristics.MethodsA systematic review and meta-analysis was performed following the PRISMA guidelines. We searched PubMed, Embase, Cochrane Library, Web of Science, and Cumulative Index of Nursing and Allied Health Literature databases for randomized controlled trials investigating the efficacy of lavender on anxiety, depression, or physiological parameters in humans. We assessed the risk of bias within studies with the revised Cochrane risk of bias tool for randomized trials. We used random effect model to estimate the average effect and computed bias-corrected standardized mean difference as effect size metric, Hedges’ ? for all outcomes.ResultsLavender was superior to placebo or no treatment in reducing anxiety (Hedges' ??=??0.72, 95% confidence interval [CI] ?0.90 to??0.55,pvalue <.001), depression (Hedges' ??=??0.43, 95% CI, ?0.59 to??0.27,pvalue <.001), and systolic blood pressure (Hedges' ??=??0.23, 95% CI,??0.41to??0.05,pvalue?=?.01). The moderator analysis by meta-regression indicated that route of administration accounted 6.5% (pvalue?=?.187) for the heterogeneity in anxiolytic effects, sessions of treatment accounted 13.2% (pvalue?=?.055), and participants’ health state accounted 8.9% (pvalue?=?.131) for the variance in anxiolytic effects.ConclusionLavender aromatherapy showed substantial effect in reducing anxiety and depression, and sessions of administration increased the anxiolytic effects. The effects on physiological parameters showed small with inconsistent significances and randomized controlled trials on the effect of lavender on depression were scarce. Future trials on depression and physiological parameters are recommended, and increasing the sessions of administration is recommended.
机译:目的最近的证据表明薰衣草的大量抗焦虑疗效。本研究的目的是研究薰衣草对焦虑,抑郁和生理参数的疗效,并通过研究特征来阐明薰衣草对焦虑和抑郁症的差异影响。在PRISMA准则之后,进行了系统审查和META分析。我们搜索了PubMed,Embase,Cochrane图书馆,科学网,以及随机对照试验的累积和盟国健康文献数据库的累积指标,调查薰衣草对人类焦虑,抑郁或生理参数的疗效。我们评估了对随机试验的偏置工具的经修订的Cochrane风险的研究中的偏见风险。我们使用随机效果模型来估计平均效果和计算的偏置校正标准化平均差异为效果规模度量,对冲?对于所有结果。培养洛拉夫曼德优于安慰剂或在减少焦虑(Hedges'= 0.72,95%置信区间[CI]Δ0.90至0.55,Pvalue <.001),抑郁症(Hedges') ?= ?? 0.43,95%CI,?0.59至约0.27,pvalue <.001),和收缩压(羽毛血压(套跑')0.23,95%CI,?? 0.41to ?? 0.05,pvalue ?=?01)。 Meta回归的主持人分析表明,给药途径占抗焦虑效应的异质性的6.5%(pvalue?= 187),治疗会计占13.2%(pvalue?= 055)和参与者的健康状态占抗焦虑作用的差异的8.9%(pvalue?=β.131)。结论劳动力芳香疗法对减少焦虑和抑郁症表现出实质性效应,并且给药的会话增加了抗焦虑作用。生理参数对生理参数的影响表明,对薰衣草对抑郁症效果的显着意义和随机对照试验稀缺。建议未来对抑郁和生理参数进行试验,建议增加行政会议。

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