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首页> 外文期刊>Bulletin of the National Research Centre >Anticytogenetic Effect of Vitamin C Against Cytogenicity of Aluminium Sulphate in Mice
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Anticytogenetic Effect of Vitamin C Against Cytogenicity of Aluminium Sulphate in Mice

机译：维生素C对小鼠硫酸铝细胞原性的抗细胞遗传作用

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摘要

Aluminium and its salts are extensively used in the household and in industry. The induction of chromosome aberrations and sister chromalid exchanges (SCE's) by aluminium sulphate was investigated in vivo bonemarrow and in vitro in spleen cell cultures of the mouse. Mice were treated orally by gavage for 1,2 and 3 weeks with 3 dose levels of aluminium sulphate 387.5, 775 and 1550 mg kg~(-1b) wt. (1/16, 1/8, 1/14 LD_(50)). The samples were taken 24 h after the last treatment. The frequency of aberrations in bonemarrow and spermatocyte cells of the mouse increased by increasing the dose and the number of treatments. The concentrations (10~(-7)-10~(-4)M) were tested for the induction of chromosome aberrations and SCE's in spleen cell cultures. Aluminium sulphate at 10~(-4)M caused a high frequency of metaphases with chromosome aberrations and SCE's after treatment of the spleen cell cultures for 24 h. Concurrent administration of vitamin C (VC) at the doses 20 mg kg~(-1b) wt. (in vivo), 5 x 10~(-6) and 5 x 10~(-5)M (in vitro) moderately minimized the genotoxic effects of aluminium sulphate in all the experiments. In conclusion, the present study indicated the genotoxic potential of aluminium sulphate and the antimutagenic effect of VC in mice.
机译：铝及其盐在家庭和工业中被广泛使用。硫酸铝诱导的染色体畸变和姊妹染色质交换（SCE's）的体内骨髓和小鼠脾细胞培养物中的体外研究。通过管饲法对小鼠口服治疗1,2和3周，使用3种剂量水平的硫酸铝387.5、775和1550 mg kg〜（-1b）wt.。 （1 / 16、1 / 8、1 / 14 LD_（50））。在最后处理后24小时取样品。通过增加剂量和治疗次数，小鼠骨髓和精细胞的畸变频率会增加。测试了浓度（10〜（-7）-10〜（-4）M）在脾细胞培养物中诱导染色体畸变和SCE。脾细胞培养24 h后，硫酸铝在10〜（-4）M时引起染色体畸变和SCE的中期转移。同时服用维生素C（VC）的剂量为20 mg kg〜（-1b）wt。 （体内），5 x 10〜（-6）和5 x 10〜（-5）M（体外）在所有实验中均将硫酸铝的遗传毒性作用最小化。总之，本研究表明了硫酸铝的遗传毒性潜力和VC对小鼠的抗诱变作用。

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