...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Bulletin of the National Research Centre >Comparative Toxicity of Malathion and its Metabolite α-(O,O-Dimethyl Phosphorodithio) Propionic Acid Ethyl Ester Towards Mice
【24h】

Comparative Toxicity of Malathion and its Metabolite α-(O,O-Dimethyl Phosphorodithio) Propionic Acid Ethyl Ester Towards Mice

机译：马拉硫磷及其代谢物α-（O，O-二甲基磷二硫代）丙酸乙酯对小鼠的比较毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The organophosphorus insecticide malathion (Ⅰ) and its metabolite α-(O, O-dimethyl phosphorodithio) propionic acid ethyl ester (Ⅱ) have been tested for their acute and subacute oral toxicity in mice. The oral LD_(50) values were determined to be 900 and 820 mg/kg, for malathion and its metabolite, respectively. Administration of both compounds to mice with one fifth and one tenth of their calculated oral LD_(50) for two weeks led to a significant depression of blood and brain cholinesterase activity in all treated groups. The maximum inhibition for brain cholinesterase activity (36-47%) and plasma (40-51%) was observed after 10 days of treatment. All treated mice returned to their normal statement after one week recovery period. Both compounds proved to have comparable toxicity towards mice.
机译：对有机磷杀虫剂马拉硫磷（Ⅰ）及其代谢产物α-（O，O-二甲基磷二硫）丙酸乙酯（Ⅱ）进行了小鼠急性和亚急性口服毒性试验。马拉硫磷及其代谢产物的口服LD_（50）值分别确定为900和820 mg / kg。两种化合物分别以其计算的口服LD_（50）的五分之一和十分之一给药于小鼠，导致所有治疗组的血液和脑胆碱酯酶活性均显着下降。治疗10天后，观察到对脑胆碱酯酶活性（36-47％）和血浆（40-51％）的最大抑制作用。一周的恢复期后，所有治疗的小鼠均恢复其正常状态。两种化合物都证明对小鼠具有可比的毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号